beta 2 Defensin Protein
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- Target Alle beta 2 Defensin (BD-2) Proteine anzeigen
- beta 2 Defensin (BD-2) (Defensin beta 2 (BD-2))
- Biologische Aktivität
- Active
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Spezies
- Human
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Quelle
- Escherichia coli (E. coli)
- Sequenz
- GIGDPVTCLK SGAICHPVFC PRRYKQIGTC GLPGTKCCKK
- Produktmerkmale
- Fully biologically active when compared to standard. The ED50 determined by a chemotaxis bioassay usingimmature human dendritic cells is less than 100 ng/ml, corresponding to a specific activity of >, 1.0 × 104 IU/mg.
- Reinheit
- > 98 % by SDS-PAGE and HPLC analyses.
- Endotoxin-Niveau
- Level Less than 1EU/µg of rHuBD-2 as determined by LAL method
- Top Product
- Discover our top product BD-2 Protein
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- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Lyophilized
- Rekonstitution
- We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at < -20 °C. Further dilutions should be made in appropriate buffered solutions.
- Lagerung
- 4 °C
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- Target
- beta 2 Defensin (BD-2) (Defensin beta 2 (BD-2))
- Andere Bezeichnung
- beta-Defensin 2 (BD-2) (BD-2 Produkte)
- Hintergrund
- Defensins (alpha and beta) are cationic peptides with a broad spectrum of antimicrobial activity that comprise an important arm of the innate immune system. The ª-defensins are distinguished from the beta-defensins by the pairing of their three disulfide bonds. To date, four human beta-defensins have been identified, BD-1, BD-2, BD-3 and BD-4. beta-defensins are expressed on some leukocytes and at epithelial surfaces. In addition to their direct antimicrobial activities, they are chemoattractant towards immature dendritic cells and memory T cells. The beta-defensin proteins are expressed as the C-terminal portion of precursors and are released by proteolytic cleavage of a signal sequence and, in the case of BD-1 (36 a.a.), a propeptide region. beta-defensins contain a six-cysteine motif that forms three intra-molecular disulfide bonds. beta-Defensins are 3-5 kDa peptides ranging in size from 33-47 amino acid residues. Synonym: beta-Defensin 2 (BD-2), Human. Formulation: Lyophilized from a 0.2µm filtered concentrated solution in 20mM PB, pH 7.4, 130mM NaCl.
- Molekulargewicht
- Approximately 4.3 KDa, a single non-glycosylated polypeptide chain containing 41 amino acids.
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