Purified recombinant Human TNF beta protein Expression System: E.coli Bioactivity: The ED50 as determined by the cytolysis of Mouse L929 cells in the presence of Actinomycin-D is ? 0.05 ng/mL, corresponding to a specific activity of ? 2 x 10^7 units/mg.
TNF-beta is a potent mediator of inflammatory and immune responses. It belongs to the TNF family of ligands and signals through TNFR1 and TNFR2. TNF-beta is produced by activated T and B lymphocytes, and has similar activities to TNF-alpha. Like TNF-alpha, TNF-beta is involved in the regulation of various biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, coagulation, and neurotransmission. TNF-beta is secreted as a soluble polypeptide, but can form heterotrimers with lymphotoxin-beta, which effectively anchors the TNF-beta to the cell surface. TNF-beta is cytotoxic to a wide range of tumor cells. Alternative Names: LT-alpha protein, TNFSF1 protein, TNF-b protein, Tumor Necrosis Factor-beta protein, TNF-beta protein, Lymphotoxin-alpha protein, TNFb protein