LTA Protein

Produktnummer ABIN935844

Dieses Recombinant LTA-Protein wird in Escherichia coli (E. coli) exprimiert.

Kurzübersicht für LTA Protein (ABIN935844)

Target: LTA (Lymphotoxin-alpha (LTA))

Protein-Typ: Recombinant

Biologische Aktivität: Active

Spezies: Chemical

Quelle: Escherichia coli (E. coli)

Reinheit: > 98 % pure

Produktdetails

Sequenz: MLPGVGLTPS AAQTARQHPK MHLAHSTLKP AAHLIGDPSK QNSLLWRANT DRAFLQDGFS LSNNSLLVPT SGIYFVYSQV VFSGKAYSPK ATSSPLYLAH EVQLFSSQYP FHVPLLSSQK MVYPGLQEPW LHSMYHGAAF QLTQGDQLST HTDGIPHLVL SPSTVFFGAF AL

Produktmerkmale: Purified recombinant Human TNF beta protein
Expression System: E.coli
Bioactivity: The ED50 as determined by the cytolysis of Mouse L929 cells in the presence of Actinomycin-D is ? 0.05 ng/mL, corresponding to a specific activity of ? 2 x 10^7 units/mg.

Endotoxin-Niveau: < 0.1 ng per µg (1 EU/µg).

Anwendungsinformationen

Applikationshinweise: Each Investigator should determine their own optimal working dilution for specific applications.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Reconstitute in Water to a concentration of 0.1-1.0 mg/mL.

Buffer: Lyophilized from 10 mM Na3PO4, pH 7.0, with 50 mM NaCl.

Handhabung: Avoid repeated freeze/thaw cycles.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 4 °C until reconstitution. Following reconstitution aliquot and freeze at -20 °C for long term storage.

Antigendetails

Target: LTA (Lymphotoxin-alpha (LTA))

Andere Bezeichnung: TNF beta

Substanzklasse: Chemical

Hintergrund: TNF-beta is a potent mediator of inflammatory and immune responses. It belongs to the TNF family of ligands and signals through TNFR1 and TNFR2. TNF-beta is produced by activated T and B lymphocytes, and has similar activities to TNF-alpha. Like TNF-alpha, TNF-beta is involved in the regulation of various biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, coagulation, and neurotransmission. TNF-beta is secreted as a soluble polypeptide, but can form heterotrimers with lymphotoxin-beta, which effectively anchors the TNF-beta to the cell surface. TNF-beta is cytotoxic to a wide range of tumor cells.
Alternative Names: LT-alpha protein, TNFSF1 protein, TNF-b protein, Tumor Necrosis Factor-beta protein, TNF-beta protein, Lymphotoxin-alpha protein, TNFb protein

Molekulargewicht: 18.6 kDa

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process