Thymic Stromal Lymphopoietin Protein (TSLP)
Kurzübersicht für Thymic Stromal Lymphopoietin Protein (TSLP) (ABIN935841)
Target
Alle Thymic Stromal Lymphopoietin (TSLP) Proteine anzeigenProtein-Typ
Spezies
Quelle
Reinheit
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Sequenz
- MYDFTNCDFE KIKAAYLSTI SKDLITYMSG TKSTEFNNTV SCSNRPHCLT EIQSLTFNPT AGCASLAKE MFAMKTKAAL AIWCPGYSET QINATQAMKK RRKRKVTTNK CLEQVSQLQG L WRRFNRPL LKQQ
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Produktmerkmale
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Purified recombinant Human TSLP protein
Expression System: E.coli -
Endotoxin-Niveau
- < 0.1 ng per µg (1 EU/µg).
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Applikationshinweise
- Each Investigator should determine their own optimal working dilution for specific applications.
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Lyophilized
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Rekonstitution
- Reconstitute in water to a concentration of 0.1 - 1.0 mg/mL.
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Buffer
- Lyophilized from NaC2H3O2, pH 6.0.
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Handhabung
- Avoid repeated freeze/thaw cycles.
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Lagerung
- 4 °C/-20 °C
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Informationen zur Lagerung
- Store at 4 °C until reconstitution. Following reconstitution aliquot and freeze at -20 °C for long term storage.
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- Thymic Stromal Lymphopoietin (TSLP)
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Andere Bezeichnung
- TSLP
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Hintergrund
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TSLP is a hemopoietic protein that is expressed in the heart, liver and prostate. TSLP overlaps biological activities with IL7 and binds with the heterodimeric receptor complex consisting of the IL7R alpha chain (IL7Ra) and the TSLP-specific chain (TSLPR). Like IL7, TSLP induces phosphorylation of STAT3 and STAT5, but uses kinases other than the JAKs for activation. TSLP prohibited apoptosis and stimulated growth of the human acute myeloid leukemia (AML)-derived cell line MUTZ3. It induces the release of T cell-attracting chemokines TARC and MDC from monocytes and activates CD11c(+) dendritic cells (DCs).
Alternative Names: Thymic Stromal Lymphopoietin protein, TSLP protein -
Molekulargewicht
- 15.0 kDa
Target
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