SOX2 Protein

Produktnummer ABIN935801

Produktdetails

Target: SOX2 (SRY (Sex Determining Region Y)-Box 2 (SOX2))

Protein-Typ: Recombinant

Spezies: Human

Quelle: Escherichia coli (E. coli)

Sequenz: MYNMMETELK PPGPQQTSGG GGGNSTAAAA GGNQKNSPDR VKRPMNAFMV WSRGQRRKMA QENPKMHNSE ISKRLGAEWK LLSETEKRPF IDEAKRLRAL HMKEHPDYKY RPRRKTKTLM KKDKYTLPGG LLAPGGNSMA SGVGVGAGLG AGVNQRMDSY AHMNGWSNGS YSMMQDQLGY PQHPGLNAHG AAQMQPMHRY DVSALQYNSM TSSQTYMNGS PTYSMSYSQQ GTPGMALGSM GSVVKSEASS SPPVVTSSSH SRAPCQAGDL RDMISMYLPG AEVPEPAAPS RLHMSQHYQS GPVPGTAING TLPLSHM

Produktmerkmale: Purified recombinant Human Sox2 protein
Expression System: E.coli

Reinheit: > 95 % pure

Endotoxin-Niveau: < 0.1 ng per µg (1 EU/µg).

Anwendungsinformationen

Applikationshinweise: Each Investigator should determine their own optimal working dilution for specific applications.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: Supplied as a lyophilized powder.

Handhabung: Avoid repeated freeze/thaw cycles.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 4 °C until reconstitution. Following reconstitution aliquot and freeze at -20 °C for long term storage.

Antigendetails

Target: SOX2 (SRY (Sex Determining Region Y)-Box 2 (SOX2))

Andere Bezeichnung: Sox2 (SOX2 Produkte)

Synonyme: ANOP3 Protein, MCOPS3 Protein, RGD1565646 Protein, Sox-2 Protein, lcc Protein, ysb Protein, cb236 Protein, wu:fb83g04 Protein, wu:fc14d07 Protein, zgc:65860 Protein, zgc:77389 Protein, SRY-box2 Protein, Xsox-2 Protein, anop3 Protein, mcops3 Protein, sox-2 Protein, SRY-box 2 Protein, SRY box 2 Protein, SRY (sex determining region Y)-box 2 Protein, SRY-box 2 S homeolog Protein, SOX2 Protein, Sox2 Protein, sox2 Protein, sox2.S Protein

Hintergrund: Sox2, also known as sex determining region Y (SRY)-box 2, belongs to a diverse family of structurally-related transcription factors whose primary structure contains a 79-residue DNA-binding domain, called high mobility group (HMG) box. It plays an essential role in maintaining the pluripotency of embryonic stem cells (ESC) and determination of cell fate. Microarray analysis showed that Sox2 regulates the expression of multiple genes involved in embryonic development including FGF4, YES1 and ZFP206. Sox2 acts as a transcriptional activator after forming a ternary complex with Oct3/4 and a conserved non-coding DNA sequence (CNS1) located approximately 2 kb upstream of the RAX promoter. The introduction of Sox2, Oct4, Myc, and Klf4, into human dermal fibroblasts isolated from a skin biopsy of a healthy research fellow was sufficient to confer a pluripotent state upon the fibroblast genome.
Alternative Names: Sox-2, Sox-2 protein, Sox 2 protein, Sex Determining Region Y- box 2 protein, Sox2, Sox-2 protein, Sox 2

Molekulargewicht: 34.3 kDa

Pathways: Dopaminergic Neurogenesis, Sensory Perception of Sound, Stem Cell Maintenance, Cell RedoxHomeostasis