RANK Receptor (Active) Protein
Spezies: Human
Wirt: Escherichia coli (E. coli)
Recombinant
> 98 % pure
Active
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- Target
- RANK Receptor
- Protein-Typ
- Recombinant
- Biologische Aktivität
- Active
- Spezies
- Human
-
Quelle
- Escherichia coli (E. coli)
- Sequenz
- MQIAPPCTSE KHYEHLGRCC NKCEPGKYMS SKCTTTSDSV CLPCGPDEYL DSWNEEDKCL LHKVCDTGKA LVAVVAGNST TPRRCACTAG YHWSQDCECC RRNTECAPGL GAQHPLQLNK DTVCKPCLAG YFSDAFSSTD KCRPWTNCTF LGKRVEHHGT EKSDAVCSSS LPARK
- Produktmerkmale
-
Purified recombinant Human RANK Receptor protein
Expression System: E.coli
Bioactivity: Determined by its ability to suppress the production of IFN-gamma from human PBMCs. - Reinheit
- > 98 % pure
- Endotoxin-Niveau
- < 0.1 ng per µg (1 EU/µg).
-
-
- Applikationshinweise
- Each Investigator should determine their own optimal working dilution for specific applications.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
-
- Format
- Lyophilized
- Rekonstitution
- Reconstitute in water to a concentration of 0.1-1.0 mg/mL.
- Buffer
- Lyophilized from 10 mM Na3PO4, pH 7.2.
- Handhabung
- Avoid repeated freeze/thaw cycles.
- Lagerung
- 4 °C/-20 °C
- Informationen zur Lagerung
- Store at 4 °C until reconstitution. Following reconstitution aliquot and freeze at -20 °C for long term storage.
-
- Target
- RANK Receptor
- Hintergrund
-
RANKL and RANK are members of the TNF superfamily of ligands and receptors that play an important role in the regulation of specific immunity and bone turnover. RANK (receptor) was originally identified as a dendritic-cell-membrane protein, which by interacting with RANKL augments the ability of dendritic cells to stimulate naive T cell proliferation and to promote the survival of RANK + T cells. RANK is also expressed in a variety of tissues including skeletal muscle, thymus, liver, colon, small intestine and adrenal gland. The RANK/RANKL interaction is important in the regulation of osteoclastogenesis and in dendritic-cell-mediated T cell immune responses. Impairments in RANK signaling have been implicated in the induction of expansile osteolysis and Paget disease of bone (PDB2).
Alternative Names: TNFRSF11A protein, osteoclast differentiation factor receptor protein, ODFR protein, osteoclast differentiation and activation receptor protein, ODAR protein, TRANCE Receptor protein - Molekulargewicht
- 19.3 kDa
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