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Platelet-Derived Growth Factor CC (PDGFCC) (Active) Protein

PDGFCC Spezies: Human Wirt: Escherichia coli (E. coli) Recombinant > 98 % pure Active
Produktnummer ABIN935736
  • Target Alle Platelet-Derived Growth Factor CC (PDGFCC) Proteine anzeigen
    Platelet-Derived Growth Factor CC (PDGFCC)
    Protein-Typ
    Recombinant
    Biologische Aktivität
    Active
    Spezies
    Human
    Quelle
    Escherichia coli (E. coli)
    Sequenz
    MVVDLNLLTE EVRLYSCTPR NFSVSIREEL KRTDTIFWPG CLLVKRCGGN CACCLHNCNE CQCVPSKVTK KYHEVLQLRP KTGVRGLHKS LTDVALEHHE ECDCVCRGST GG
    Produktmerkmale
    Purified recombinant Human PDGF CC protein
    Expression System: E.coli
    Bioactivity: Determined by the dose-dependent stimulation of the proliferation of Balb/c 3T3 cells. The expected The ED50 for this effect is 15-20 ng/mL.
    Reinheit
    > 98 % pure
    Endotoxin-Niveau
    < 0.1 ng per µg (1 EU/µg).
  • Applikationshinweise
    Each Investigator should determine their own optimal working dilution for specific applications.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Buffer
    Supplied as a lyophilized powder.
    Handhabung
    Avoid repeated freeze/thaw cycles.
    Lagerung
    4 °C/-20 °C
    Informationen zur Lagerung
    Store at 4 °C until reconstitution. Following reconstitution aliquot and freeze at -20 °C for long term storage.
  • Target
    Platelet-Derived Growth Factor CC (PDGFCC)
    Andere Bezeichnung
    PDGF CC (PDGFCC Produkte)
    Synonyme
    1110064L01Rik Protein, AI647969 Protein, PDGF-C Protein, SCDGF Protein, platelet-derived growth factor, C polypeptide Protein, platelet derived growth factor C Protein, Pdgfc Protein
    Hintergrund
    The platelet-derived growth factor (PDGF) family of heparin-binding growth factors consists of five known members, denoted PDGF-AA, PDGF-BB, PDGF-AB, PDGF-CC and PDGF-DD. The mature and active form of these proteins, an anti-parallel disulfide-linked dimer of two 12-14 kDa polypeptide chains, is obtained through proteolytic processing of biologically inactive precursor proteins, which contain an N-terminal CUB domain and a PDGF/VEGF homologous domain. The PDGFs interact with two related protein tyrosine kinase receptors, PDGFR-a and PDGFR-beta, and are potent mitogens for a variety of cell types, including smooth muscle cells, connective tissue cells, bone and cartilage cells, and certain tumor cells.
    Alternative Names: Osteosarcoma-derived Growth Factor protein, Platelet-Derived Growth Factor-CC protein, ODGF protein, Glioma-derived growth factor protein, PCGF protein, GDGF protein
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