Platelet-Derived Growth Factor CC (PDGFCC) (Active) Protein
PDGFCC
Spezies: Human
Wirt: Escherichia coli (E. coli)
Recombinant
> 98 % pure
Active
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- Target Alle Platelet-Derived Growth Factor CC (PDGFCC) Proteine anzeigen
- Platelet-Derived Growth Factor CC (PDGFCC)
- Protein-Typ
- Recombinant
- Biologische Aktivität
- Active
- Spezies
- Human
- Quelle
- Escherichia coli (E. coli)
- Sequenz
- MVVDLNLLTE EVRLYSCTPR NFSVSIREEL KRTDTIFWPG CLLVKRCGGN CACCLHNCNE CQCVPSKVTK KYHEVLQLRP KTGVRGLHKS LTDVALEHHE ECDCVCRGST GG
- Produktmerkmale
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Purified recombinant Human PDGF CC protein
Expression System: E.coli
Bioactivity: Determined by the dose-dependent stimulation of the proliferation of Balb/c 3T3 cells. The expected The ED50 for this effect is 15-20 ng/mL. - Reinheit
- > 98 % pure
- Endotoxin-Niveau
- < 0.1 ng per µg (1 EU/µg).
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- Applikationshinweise
- Each Investigator should determine their own optimal working dilution for specific applications.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Lyophilized
- Buffer
- Supplied as a lyophilized powder.
- Handhabung
- Avoid repeated freeze/thaw cycles.
- Lagerung
- 4 °C/-20 °C
- Informationen zur Lagerung
- Store at 4 °C until reconstitution. Following reconstitution aliquot and freeze at -20 °C for long term storage.
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- Target
- Platelet-Derived Growth Factor CC (PDGFCC)
- Andere Bezeichnung
- PDGF CC (PDGFCC Produkte)
- Hintergrund
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The platelet-derived growth factor (PDGF) family of heparin-binding growth factors consists of five known members, denoted PDGF-AA, PDGF-BB, PDGF-AB, PDGF-CC and PDGF-DD. The mature and active form of these proteins, an anti-parallel disulfide-linked dimer of two 12-14 kDa polypeptide chains, is obtained through proteolytic processing of biologically inactive precursor proteins, which contain an N-terminal CUB domain and a PDGF/VEGF homologous domain. The PDGFs interact with two related protein tyrosine kinase receptors, PDGFR-a and PDGFR-beta, and are potent mitogens for a variety of cell types, including smooth muscle cells, connective tissue cells, bone and cartilage cells, and certain tumor cells.
Alternative Names: Osteosarcoma-derived Growth Factor protein, Platelet-Derived Growth Factor-CC protein, ODGF protein, Glioma-derived growth factor protein, PCGF protein, GDGF protein
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