14-3-3 sigma/SFN Protein (AA 1-248)

Produktnummer ABIN935074

Recombinant 14-3-3 sigma/SFN-Protein exprimiert in Escherichia coli (E. coli).

Kurzübersicht für 14-3-3 sigma/SFN Protein (AA 1-248) (ABIN935074)

Target: 14-3-3 sigma/SFN (SFN) (Stratifin (SFN))

Protein-Typ: Recombinant

Spezies: Human

Quelle: Escherichia coli (E. coli)

Applikation: SDS-PAGE (SDS)

Reinheit: > 95 % pure

Produktdetails

Proteineigenschaft: AA 1-248

Sequenz: MERASLIQKA KLAEQAERYE DMAAFMKGAV EKGEELSCEE RNLLSVAYKN VVGGQRAAWR VLSSIEQKSN EEGSEEKGPE VREYREKVET ELQGVCDTVL GLLDSHLIKE AGDAESRVFY LKMKGDYYRY LAEVATGDDK KRIIDSARSA YQEAMDISKK EMPPTNPIRL GLALNFSVFH YEIANSPEEA ISLAKTTFDE AMADLHTLSE DSYKDSTLIM QLLRDNLTLW TADNAGEEGG EAPQEPQS

Produktmerkmale: Purified recombinant Human 14.3.3 sigma protein
Expression System: E.coli

Anwendungsinformationen

Applikationshinweise: 14.3.3 Sigma protein has been used in SDS PAGE and may be suitable for use in other assays to be determined by the end user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Supplied as a liquid in 20 mM Tris-HCl buffer, pH 8.0, containing 50 mM NaCl and 10 % glycerol.

Handhabung: Avoid repeated freeze/thaw cycles.

Lagerung: RT/-20 °C

Informationen zur Lagerung: Store at 4 °C for short term storage (1/2 weeks). Aliquot and store at -20 °C or - 70 °C for long term storage.

Antigendetails

Target: 14-3-3 sigma/SFN (SFN) (Stratifin (SFN))

Andere Bezeichnung: 14.3.3 sigma

Hintergrund: 14-3-3 sigma, also known as Stratifin (SFN), belongs to the 14-3-3 family. The 14-3-3 family of proteins plays a key regulatory role in signal transduction, checkpoint control, apoptotic and nutrient-sensing pathways. 14-3-3 proteins are highly conserved and ubiquitously expressed. There are at least seven isoforms, beta, gamma, epsilon, sigma, zeta, tau and eta that have been identified in mammals. 14-3-3 sigma was identified as an epithelial cell marker and appeared to function as a tumor suppressor whose expression can be down regulated via methylation. Loss of 14-3-3 sigma expression results in a defective G2/M phase checkpoint and appears to contribute to both epithelial and non-epithelial tumorigenesis. Recombinant human 14-3-3 sigma was expressed in E. coli and purified by using conventional chromatography techniques.
Alternative Names: HME1 protein, SFN protein, 14.3.3 sigma, Epithelial cell marker protein 1 protein, stratifin protein, 14-3-3 sigma protein, 14/3/3 sigma protein, YWHAS protein, 14-3-3 sigma, 14/3/3 sigma, 14-3-3 sigma

Molekulargewicht: 27.7 kDa (248 AA)

Pathways: p53 Signalweg, Myometrial Relaxation and Contraction