STUB1 Protein (AA 1-303)

Produktnummer ABIN935009

Produktdetails

Target: STUB1 (STIP1 Homology and U-Box Containing Protein 1 (STUB1))

Protein-Typ: Recombinant

Proteineigenschaft: AA 1-303

Spezies: Human

Quelle: Escherichia coli (E. coli)

Applikation: SDS-PAGE (SDS)

Sequenz: MKGKEEKEGG ARLGAGGGSP EKSPSAQELK EQGNRLFVGR KYPEAAACYG RAITRNPLVA VYYTNRALCY LKMQQHEQAL ADCRRALELD GQSVKAHFFL GQCQLEMESY DEAIANLQRA YSLAKEQRLN FGDDIPSALR IAKKKRWNSI EERRIHQESE LHSYLSRLIA AERERELEEC QRNHEGDEDD SHVRAQQACI EAKHDKYMAD MDELFSQVDE KRKKRDIPDY LCGKISFELM REPCITPSGI TYDRKDIEEH LQRVGHFDPV TRSPLTQEQL IPNLAMKEVI DAFISENGWV EDY

Produktmerkmale: Purified recombinant Human CHIP protein
Expression System: E.coli
Molecular weight on SDS-PAGE will appear higher.

Reinheit: > 90 % pure

Endotoxin-Niveau: < 1.0 EU per µg of protein (determined by LAL method)

Anwendungsinformationen

Applikationshinweise: CHIP protein has been used in SDS PAGE and may be suitable for use in other assays to be determined by the end user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Supplied as a liquid in 20 mM Tris-HCl buffer, pH 7.5, containing 0 mM DTT, and 10 % glycerol.

Konservierungsmittel: Dithiothreitol (DTT)

Vorsichtsmaßnahmen: This product contains Dithiothreitol: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handhabung: Avoid repeated freeze/thaw cycles.

Lagerung: RT/-20 °C

Informationen zur Lagerung: Store at 4 °C for short term storage (1/2 weeks). Aliquot and store at -20 °C or - 70 °C for long term storage.

Antigendetails

Target: STUB1 (STIP1 Homology and U-Box Containing Protein 1 (STUB1))

Andere Bezeichnung: CHIP (STUB1 Produkte)

Hintergrund: CHIP, also known as STUB1, is a cytoplasmic protein whose amino acid sequence is highly conserved across species. CHIP interacts with the molecular chaperones Hsc70-Hsp70 and Hsp90 through its TPR domain, whereas its U-box domain contains its E3 ubiquitin ligase activity. Its interaction with these molecular chaperones results in client substrate ubiquitylation and degradation by the proteasome. Thus, CHIP acts to tilt the folding-refolding machinery toward the degradative pathway, and it serves as a link between the two. Recombinant human CHIP protein was expressed in E. coli and purified by using conventional chromatography techniques.
Alternative Names: NY CO 7 protein, STUB 1 protein, CHIP protein, HSPABP2 protein, STIP1 homology and U Box containing protein 1., E3 ubiquitin protein ligase CHIP protein, STUB1 protein, UBOX1 protein, Carboxy terminus of HSP70 interacting protein protein NY CO 7 protein, SDCCAG7 protein, UBOX 1 protein, NY-CO-7 protein, Carboxy terminus of Hsp70p interacting protein protein, Serologically defined colon cancer protein 7 protein, CLL associated protein KW 8 protein, Heat shock protein A binding protein 2 (c terminal) protein

Molekulargewicht: 34.8 kDa (303 AA)

Pathways: Regulation of Hormone Metabolic Process, Response to Water Deprivation