HIV-1 Transmembrane Glycoprotein (HIV-1 gp41) (AA 546-682), (Ecto Domain) Protein

Produktnummer ABIN934613

Produktdetails

Target: HIV-1 Transmembrane Glycoprotein (HIV-1 gp41)

Protein-Typ: Recombinant

Proteineigenschaft: Ecto Domain, AA 546-682

Spezies: Human Immunodeficiency Virus (HIV)

Quelle: Hefe

Applikation: ELISA, Western Blotting (WB)

Produktmerkmale: Purified recombinant HIV1 gp41 protein
Expression System: Yeast
This protein comprises of Ecto-domain of gp41 from Strain HxB2, amino acids 546 to 682

Reinheit: > 99 % pure

Anwendungsinformationen

Applikationshinweise: Each Investigator should determine their own optimal working dilution for specific applications.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Supplied as a liquid in 20 mM Sodium Phosphate buffer, 500 mM NaCl, 0.2 % Triton X-100, and 6 M Urea, pH 7.4.

Handhabung: Avoid repeated freeze/thaw cycles.

Lagerung: -80 °C

Informationen zur Lagerung: Aliquot and store at -70 °C or lower.

Referenzen

Du, Idiart, Mariano, Chen, Jiang, Xu, Ostrow, Wrin, Phung, Binley, Petropoulos, Ballantyne, Whalen: "Effect of trimerization motifs on quaternary structure, antigenicity, and immunogenicity of a noncleavable HIV-1 gp140 envelope glycoprotein." in: Virology, Vol. 395, Issue 1, pp. 33-44, (2009) (PubMed).

Opalka, Pessi, Bianchi, Ciliberto, Schleif, McElhaugh, Danzeisen, Geleziunas, Miller, Eckert, Bramhill, Joyce, Cook, Magilton, Shiver, Emini, Esser: "Analysis of the HIV-1 gp41 specific immune response using a multiplexed antibody detection assay." in: Journal of immunological methods, Vol. 287, Issue 1-2, pp. 49-65, (2004) (PubMed).

Antigendetails

Target: HIV-1 Transmembrane Glycoprotein (HIV-1 gp41)

Andere Bezeichnung: HIV1 gp41

Substanzklasse: Viral Protein

Hintergrund: HIV gp41 is a glycoprotein subunit that remains non-covalently-bound to gp120, and provides the second step by which HIV enters the cell. It is originally buried within the viral envelope, but, when gp120 binds to a CD4, gp120 changes its conformation, causing gp41 to become exposed, where it can assist in fusion with the host cell. The Env gene does not, in fact, code for gp120 and gp41, but for a precursor to both, gp160. During HIV reproduction, the host cell's own enzymes cleave gp160 into gp120 and gp41.
Alternative Names: HIV-1 gp41 protein, SU antigen, Surface protein antigen, HIV1 gp41, Envelope surface glycoprotein gp41 antigen, HIV-1 gp41, Human Immunodeficiency Virus 1 antigen, gp41 antigen, HIV 1 gp41, HIV 1 gp41 protein, gp41 glycoprotein antigen, gp41 antigen, Glycoprotein 41 antigen, HIV 1 gp41 antigen, HIV-1 gp41 antigen