ADPRHL2 Protein

Produktnummer ABIN7939788

Dieses Recombinant ADPRHL2-Protein wird in Escherichia coli (E. coli) exprimiert.

Kurzübersicht für ADPRHL2 Protein (ABIN7939788)

Target: ADPRHL2 (ADP-Ribosylhydrolase Like 2 (ADPRHL2))

Protein-Typ: Recombinant

Spezies: Human

Quelle: Escherichia coli (E. coli)

Applikation: Activity Assay (AcA), Functional Studies (Func), Screening Assay (ScA)

Produktdetails

Verwendungszweck: Recombinant ADPRS / ARH3 protein

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Recombinant ADPRS / ARH3 protein is supplied in 25 mM Tris 8.0, 300 mM NaCl, 20 % glycerol, 0.5 mM TCEP.

Handhabung: Avoid repeated freeze/thaw cycles,keep on ice when not in storage

Lagerung: -80 °C

Informationen zur Lagerung: Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.

Antigendetails

Target: ADPRHL2 (ADP-Ribosylhydrolase Like 2 (ADPRHL2))

Andere Bezeichnung: ADPRS & ARH3

Hintergrund:

Protein Background: Protein ADP-ribosylation is a highly dynamic post-translational modification. The rapid turnover is achieved, among others, by ADP (ribosyl)hydrolases (ARHs), an ancient family of enzymes that reverses this modification. Recently ARHs came into focus due to their role as regulators of cellular stresses and tumor suppressors. ADPRS / ARH3 (ADPribosylhydrolase ARH3) as one of ARHs, it plays a variety of functions in organisms.It preferentially hydrolyzes the scissile alpha-O-linkage attached to the anomeric C1'' position of ADP-ribose and acts on different substrates, such as proteins ADP-ribosylated on serine and threonine, free poly(ADP-ribose) and O-acetyl-ADP-D ribose. Specifically acts as a serine mono-ADP-ribosylhydrolase by mediating the removal of mono-ADP-ribose attached to serine residues on proteins, thereby playing a key role in DNA damage response. Also able to degrade protein free poly(ADP-ribose), which is synthesized in response to DNA damage: free poly(ADP-ribose) acts as a potent cell death signal and its degradation by ADPRHL2 protects cells from poly(ADP-ribose)-dependent cell death, a process named parthanatos.

Short Description: Recombinant ADPRS / ARH3 protein that includes full length of the human ADPRS / ARH3 protein (accession number NP_060295.1) was expressed in E.coli cells with an N-terminal His tag, The molecular weight of the protein is 41.11 kDa.

Aliases: ADP-Ribosylserine Hydrolase, ARH3, ADPRHL2, ADPRS, ADPRHL2, FLJ20446