UBA7 Protein

Produktnummer ABIN7939725

Dieses Recombinant UBA7-Protein wird in Baculovirus infected Insect Cells produziert.

Kurzübersicht für UBA7 Protein (ABIN7939725)

Target: UBA7 (Ubiquitin-Like Modifier Activating Enzyme 7 (UBA7))

Protein-Typ: Recombinant

Spezies: Human

Quelle: Baculovirus infected Insect Cells

Applikation: Activity Assay (AcA), Functional Studies (Func), Screening Assay (ScA)

Produktdetails

Verwendungszweck: Recombinant UBA7 (UBE1L) protein

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Recombinant UBA7 (UBE1L) protein is supplied in 25 mM HEPES pH 7.5, 300 mM NaCl, 20 % glycerol, 0.04 % Triton X-100, 0.5 mM TCEP.

Handhabung: Avoid repeated freeze/thaw cycles,keep on ice when not in storage

Lagerung: -80 °C

Informationen zur Lagerung: Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.

Antigendetails

Target: UBA7 (Ubiquitin-Like Modifier Activating Enzyme 7 (UBA7))

Andere Bezeichnung: UBA7

Hintergrund:

Protein Background: UBA7 is an E1-activating enzyme that catalyzes the covalent conjugation of the ubiquitin-like protein product of ISG15 to additional interferon stimulated proteins (ISGs) as well as other cellular proteins such as P53 in a process termed protein ISGylation. Plays an essential role in antiviral immunity together with ISG15 by restricting the replication of many viruses including rabies virus, influenza virus, sindbis virus, rotavirus or human cytomegalovirus. For example, ISG15 modification of influenza A protein NS1 disrupts the association of the NS1 with importin-alpha leading to NS1 nuclear import inhibition. ISGylation of human cytomegalovirs protein UL26 regulates its stability and inhibits its activities to suppress NF-kappa-B signaling.

Short Description: Recombinant UBA7 (UBE1L) protein was expressed in a baculovirus expression system as the full length protein (accession number NP_003326.2) with an N-terminal FLAG tag. The molecular weight of UBA7 is 112.96 kDa.

Aliases: UBE2, D8, UBA1B, UBE1L, Ubiquitin Like Modifier Activating Enzyme