UBA1 Protein

Produktnummer ABIN7939723

Dieses Recombinant UBA1-Protein wird in Baculovirus infected Insect Cells exprimiert.

Kurzübersicht für UBA1 Protein (ABIN7939723)

Target: UBA1 (Ubiquitin-Like Modifier Activating Enzyme 1 (UBA1))

Protein-Typ: Recombinant

Spezies: Human

Quelle: Baculovirus infected Insect Cells

Applikation: Activity Assay (AcA), Functional Studies (Func), Screening Assay (ScA)

Produktdetails

Verwendungszweck: Recombinant UBA1 protein

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Recombinant UBA1 protein is supplied in 25 mM HEPES pH 7.5, 500 mM NaCl, 20 % glycerol, 0.04 % Triton X-100, 0.5 mM TCEP.

Handhabung: Avoid repeated freeze/thaw cycles,keep on ice when not in storage

Lagerung: -80 °C

Informationen zur Lagerung: Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.

Antigendetails

Target: UBA1 (Ubiquitin-Like Modifier Activating Enzyme 1 (UBA1))

Andere Bezeichnung: UBA1

Hintergrund:

Protein Background: UBA1 (Ubiquitin-like modifier-activating) also known as A1S9, A1S9T, A1ST, AMCX1, CFAP124, GXP1, POC20, SMAX2, UBA1A, UBE1, UBE1X and VEXAS. UBA1 catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation through the ubiquitin-proteasome system. Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP. Essential for the formation of radiation-induced foci, timely DNA repair and for response to replication stress. Promotes the recruitment of TP53BP1 and BRCA1 at DNA damage sites.

Short Description: Recombinant UBA1 protein that includes full length of human UBA1 protein (accession number NP_003325.2) was expressed in Sf9 cells and contains an N-terminal FLAG tag with a molecular weight of 119.12 kDa. The purity of the protein is ≥ 95 % by SDS-PAGE.

Aliases: Ubiquitin-like modifier-activating, A1S9, A1S9T, A1ST, GXP1, UBE1, A1S9T, AMCX1, POC20, SMAX2, UBA1A, UBE1X, CFAP124