MECP2 Protein (AA 80-166)

Produktnummer ABIN7939270

Dieses Recombinant MECP2-Protein wird in Escherichia coli (E. coli) exprimiert.

Kurzübersicht für MECP2 Protein (AA 80-166) (ABIN7939270)

Target: MECP2 (Methyl CpG Binding Protein 2 (MECP2))

Protein-Typ: Recombinant

Spezies: Human

Quelle: Escherichia coli (E. coli)

Applikation: Activity Assay (AcA), Functional Studies (Func), Screening Assay (ScA)

Produktdetails

Proteineigenschaft: AA 80-166

Verwendungszweck: Recombinant MECP2 (80-166) protein

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Recombinant MECP2 (80-166) protein is supplied in 25 mM Tris 8.0, 300 mM NaCl, 20 % glycerol, 0.5 mM TCEP.

Handhabung: Avoid repeated freeze/thaw cycles,keep on ice when not in storage

Lagerung: -80 °C

Informationen zur Lagerung: Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.

Antigendetails

Target: MECP2 (Methyl CpG Binding Protein 2 (MECP2))

Andere Bezeichnung: MECP2

Hintergrund:

Protein Background: MECP2 (Methyl-CpG-binding protein 2) is a chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Mediates transcriptional repression through interaction with histone deacetylase and the corepressor SIN3A. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5 methylcytosine (5mC).

Short Description: Recombinant MECP2 (80-166) protein that includes amino acids 80-166 of human MECP2 protein (accession number NP_004983.1) was expressed in E. coli cells with an N-terminal 6xHis tag. The molecular weight of the protein is 12.19 kDa.

Aliases: Methyl-CpG-binding protein 2, MeCp-2 Protein, MRX16, MRX79, RTT

Pathways: Inositol Metabolic Process, Chromatin Binding, Synaptic Membrane