KAT6B Protein (AA 718-1008, full length)

Produktnummer ABIN7939228

Dieses Recombinant KAT6B-Protein wird in Baculovirus infected Insect Cells exprimiert.

Kurzübersicht für KAT6B Protein (AA 718-1008, full length) (ABIN7939228)

Target: KAT6B (K(lysine) Acetyltransferase 6B (KAT6B))

Protein-Typ: Recombinant

Spezies: Human

Quelle: Baculovirus infected Insect Cells

Applikation: Activity Assay (AcA), Functional Studies (Func), Screening Assay (ScA)

Produktdetails

Proteineigenschaft: AA 718-1008, full length

Verwendungszweck: Recombinant KAT6B / MORF (718-1008) protein

Produktmerkmale: KAT6B (Lysine Acetyltransferase 6B), also called as MOZ2, MORF or MYST4, is a histone acetyltransferase and component of the MOZ/MORF protein complex. It has a histone H3 acetyltransferase activity. In addition to its acetyltransferase activity, the encoded full length protein has transcriptional activation activity in its N-terminal end and transcriptional repression activity in its C-terminal end. So it may be involved in both positive and negative regulation of transcription. KAT6B is necessary for RUNX2-dependent transcriptional activation and could be involved in brain development. Mutations have been found in patients with genitopatellar syndrome. A translocation of KAT6B gene and the CREBBP gene results in acute myeloid leukemias. It may also be involved in cerebral cortex development.

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Recombinant KAT6B / MORF (718-1008) protein is supplied in 25 mM HEPES-NaOH pH 7.5, 300 mM NaCl, 10 % glycerol, 0.04 % Triton X-100, 0.5 mM TCEP.

Handhabung: Avoid repeated freeze/thaw cycles,keep on ice when not in storage

Lagerung: -80 °C

Informationen zur Lagerung: Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.

Antigendetails

Target: KAT6B (K(lysine) Acetyltransferase 6B (KAT6B))

Andere Bezeichnung: KAT6B & MORF

Hintergrund:

Protein Background: KAT6B (Lysine Acetyltransferase 6B), also called as MOZ2, MORF or MYST4, is a histone acetyltransferase and component of the MOZ/MORF protein complex. It has a histone H3 acetyltransferase activity. In addition to its acetyltransferase activity, the encoded full length protein has transcriptional activation activity in its N-terminal end and transcriptional repression activity in its C-terminal end. So it may be involved in both positive and negative regulation of transcription. KAT6B is necessary for RUNX2-dependent transcriptional activation and could be involved in brain development. Mutations have been found in patients with genitopatellar syndrome. A translocation of KAT6B gene and the CREBBP gene results in acute myeloid leukemias. It may also be involved in cerebral cortex development.

Short Description: Recombinant KAT6B / MORF (718-1008) protein that includes amino acids 718-1008 of human KAT6B protein (accession number NP_036462.2) was expressed in a baculovirus expression system and contains an N-terminal FLAG tag. The molecular weight of the protein is 35.7 kDa. This product is the catalytic domain of KAT6B protein.

Aliases: MYST4, Lysine Acetyltransferase 6B