GAMT Protein

Produktnummer ABIN7938894

Dieses Recombinant GAMT-Protein wird in Escherichia coli (E. coli) produziert.

Kurzübersicht für GAMT Protein (ABIN7938894)

Target: GAMT (Guanidinoacetate N-Methyltransferase (GAMT))

Protein-Typ: Recombinant

Spezies: Human

Quelle: Escherichia coli (E. coli)

Applikation: Activity Assay (AcA), Functional Studies (Func), Screening Assay (ScA)

Produktdetails

Verwendungszweck: Recombinant GAMT protein

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Recombinant GAMT protein is supplied in 25 mM Tris pH 8.0, 300 mM NaCl, 10 % glycerol, 0.5 mM TCEP.

Handhabung: Avoid repeated freeze/thaw cycles,keep on ice when not in storage

Lagerung: -80 °C

Informationen zur Lagerung: Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.

Antigendetails

Target: GAMT (Guanidinoacetate N-Methyltransferase (GAMT))

Andere Bezeichnung: GAMT

Hintergrund:

Protein Background: Guanidinoacetate N-methyltransferase is also known as GAMT.The main function of GAMT is Converts guanidinoacetate to creatine, using S-adenosylmethionine as the methyl donor.Guanidinoacetate methyltransferase (GAMT) deficiency is an autosomal recessively inherited disorder of creatine biosynthesis . GAMT enzyme deficiency caused by mutations in the GAMT gene results in the depletion of creatine and accumulation of guanidinoacetate (GAA). Creatine has a buffering and transport function of high-energy phosphates in brain and muscle and is essential for growth cone migration, dendritic and axonal elongation, neurotransmitter release, and cotransmission on gamma amino butyric acid (GABA) postsynaptic receptors in the central nervous system.

Short Description: Recombinant GAMT protein was expressed in E.coli as the full length protein (accession number NP_000147.1) with an N-terminal 6xHis tag. The molecular weight of the protein is 28.11 kDa.

Aliases: Guanidinoacetate N-methyltransferase