DDX54 Protein

Produktnummer ABIN7938756

Dieses Recombinant DDX54-Protein wird in Baculovirus infected Insect Cells produziert.

Kurzübersicht für DDX54 Protein (ABIN7938756)

Target: DDX54 (DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 54 (DDX54))

Protein-Typ: Recombinant

Spezies: Human

Quelle: Baculovirus infected Insect Cells

Applikation: Activity Assay (AcA), Functional Studies (Func), Screening Assay (ScA)

Produktdetails

Verwendungszweck: Recombinant DDX54 protein

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Recombinant DDX54 protein is supplied in 25 mM HEPES pH 7.5, 300 mM NaCl, 20 % glycerol, 0.04 % Triton X-100, 0.5 mM TCEP.

Handhabung: Avoid repeated freeze/thaw cycles,keep on ice when not in storage

Lagerung: -80 °C

Informationen zur Lagerung: Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.

Antigendetails

Target: DDX54 (DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 54 (DDX54))

Andere Bezeichnung: DDX54

Hintergrund:

Protein Background: DDX54 (ATP-dependent RNA helicase DDX54) is a nucleolar DEAD-box RNA helicase that functions as a key regulator of transcription and ribosome biogenesis. It is recruited to gene promoters, including those of nuclear receptors and stress-responsive genes, where it acts as a transcriptional co-regulator to modulate their expression. Furthermore, DDX54 plays a direct role in the nucleolar stages of ribosomal RNA (rRNA) processing and maturation, which is essential for the proper assembly of ribosomes. Its activity is also implicated in the cellular stress response, where it contributes to the reorganization of nucleolar architecture and halts rRNA synthesis to conserve energy. Dysregulation of DDX54 has been associated with cancers, underscoring its importance in fundamental cell growth and proliferation pathways.

Short Description: Recombinant DDX54 protein was expressed in a baculovirus expression system as the full length protein (accession number NP_001104792.1) with an N-terminal FLAG tag. The molecular weight of DDX54 is 99.94 kDa.

Aliases: ATP-dependent RNA helicase DDX54, DP97, DEAD-Box Helicase 54

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway