DDX3X Protein

Produktnummer ABIN7938752

Dieses Recombinant DDX3X-Protein wird in Baculovirus infected Insect Cells produziert.

Kurzübersicht für DDX3X Protein (ABIN7938752)

Target: DDX3X (DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 3, X-Linked (DDX3X))

Protein-Typ: Recombinant

Spezies: Human

Quelle: Baculovirus infected Insect Cells

Applikation: Activity Assay (AcA), Functional Studies (Func), Screening Assay (ScA)

Produktdetails

Verwendungszweck: Recombinant DDX3X protein

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Recombinant DDX3X protein is supplied in 25 mM HEPES pH 7.5, 300 mM NaCl, 20 % glycerol, 0.04 % Triton X-100, 0.5 mM TCEP.

Handhabung: Avoid repeated freeze/thaw cycles,keep on ice when not in storage

Lagerung: -80 °C

Informationen zur Lagerung: Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.

Antigendetails

Target: DDX3X (DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 3, X-Linked (DDX3X))

Andere Bezeichnung: DDX3X

Hintergrund:

Protein Background: DDX3X (ATP-dependent RNA helicase DDX3X) is a multifunctional ATP-dependent RNA helicase belonging to the DEAD-box protein family, which is critically involved in numerous aspects of RNA metabolism. Its primary function is to unwind RNA secondary structures, an essential activity that facilitates key processes including transcription, mRNA splicing, nuclear export, translation initiation, and the assembly of stress granules. Furthermore, DDX3X plays vital roles in innate immune signaling pathways by modulating the activity of key kinases and interferon responses. Due to its central role in gene expression and cell growth, mutations in the DDX3X gene are linked to neurodevelopmental disorders and various cancers, highlighting its importance in cellular homeostasis and disease.

Short Description: Recombinant DDX3X protein was expressed in a baculovirus expression system as the full length protein (accession number NP_001347.3) with an N-terminal FLAG tag. The molecular weight of DDX3X is 74.51 kDa.

Aliases: ATP-dependent RNA helicase DDX3X, DEAD-Box Helicase, DDX3X, DDX3, HLP2

Pathways: Ribonucleoprotein Complex Subunit Organization, Positive Regulation of Endopeptidase Activity, Negative Regulation of intrinsic apoptotic Signaling, Ribosome Assembly