CIAPIN1 Protein

Produktnummer ABIN7938747

Dieses Recombinant CIAPIN1-Protein wird in Escherichia coli (E. coli) produziert.

Kurzübersicht für CIAPIN1 Protein (ABIN7938747)

Target: CIAPIN1 (Cytokine Induced Apoptosis Inhibitor 1 (CIAPIN1))

Protein-Typ: Recombinant

Spezies: Human

Quelle: Escherichia coli (E. coli)

Applikation: Activity Assay (AcA), Functional Studies (Func), Screening Assay (ScA)

Produktdetails

Verwendungszweck: Recombinant CIAPIN1 protein

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Recombinant CIAPIN1 protein is supplied in 25 mM Tris pH 8.0, 300 mM NaCl, 10 % glycerol, 0.5 mM TCEP.

Handhabung: Avoid repeated freeze/thaw cycles,keep on ice when not in storage

Lagerung: -80 °C

Informationen zur Lagerung: Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.

Antigendetails

Target: CIAPIN1 (Cytokine Induced Apoptosis Inhibitor 1 (CIAPIN1))

Andere Bezeichnung: CIAPIN1

Hintergrund:

Protein Background: CIAPIN1 (Cytokine-induced apoptosis inhibitor 1,also known as Anamorsin or Fe-S cluster assembly protein DRE2 homolog) is a Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex NUBP1-NUBP2. Electrons are transferred to CIAPIN1 from NADPH via the FAD- and FMN-containing protein NDOR1 . NDOR1-CIAPIN1 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit (By similarity).Has anti-apoptotic effects in the cell. Involved in negative control of cell death upon cytokine withdrawal. Promotes development of hematopoietic cells (By similarity).

Short Description: Recombinant CIAPIN1 protein was expressed in E.coli as the full length protein (accession number NP_064709.2) with an N-terminal 6xHis tag. The molecular weight of the protein is 35.38 kDa.

Aliases: Anamorsin, DRE2, cytokine induced apoptosis inhibitor 1