CHD1L Protein

Produktnummer ABIN7938710

Recombinant CHD1L-Protein exprimiert in Baculovirus infected Insect Cells.

Kurzübersicht für CHD1L Protein (ABIN7938710)

Target: CHD1L (Chromodomain Helicase DNA Binding Protein 1-Like (CHD1L))

Protein-Typ: Recombinant

Spezies: Human

Quelle: Baculovirus infected Insect Cells

Applikation: Activity Assay (AcA), Functional Studies (Func), Screening Assay (ScA)

Produktdetails

Verwendungszweck: Recombinant CHD1L protein

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Recombinant CHD1L protein is supplied in 25 mM HEPES pH 7.5, 300 mM NaCl, 20 % glycerol, 0.04 % Triton X-100, 0.5 mM TCEP.

Handhabung: Avoid repeated freeze/thaw cycles,keep on ice when not in storage

Lagerung: -80 °C

Informationen zur Lagerung: Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.

Antigendetails

Target: CHD1L (Chromodomain Helicase DNA Binding Protein 1-Like (CHD1L))

Andere Bezeichnung: CHD1L

Hintergrund:

Protein Background: CHD1L is a ATP-dependent chromatin remodeler that mediates chromatin-remodeling following DNA damage. Recruited to DNA damage sites through interaction with poly-ADP-ribose: specifically recognizes and binds histones that are poly-ADP-ribosylated on serine residues in response to DNA damage. Poly-ADP-ribose-binding activates the ATP-dependent chromatin remodeler activity, thereby regulating chromatin during DNA repair. Catalyzes nucleosome sliding away from DNA breaks in an ATP dependent manner. Chromatin remodeling activity promotes PARP2 removal from chromatin.

Short Description: Recombinant CHD1L protein was expressed in a baculovirus expression system as the full-length protein (accession number NP_004275.4) with an N-terminal FLAG tag. The molecular weight of CHD1L is 102.27 kDa.

Aliases: ALC1, Amplified In Liver Cancer Protein 1, CHDL