CDC42BPB Protein (AA 1-473)

Produktnummer ABIN7938684

Dieses Recombinant CDC42BPB-Protein wird in Baculovirus infected Insect Cells exprimiert.

Kurzübersicht für CDC42BPB Protein (AA 1-473) (ABIN7938684)

Target: CDC42BPB (CDC42 Binding Protein Kinase beta (DMPK-Like) (CDC42BPB))

Protein-Typ: Recombinant

Spezies: Human

Quelle: Baculovirus infected Insect Cells

Applikation: Functional Studies (Func), Activity Assay (AcA), Screening Assay (ScA)

Produktdetails

Proteineigenschaft: AA 1-473

Verwendungszweck: Recombinant MRCKb / CDC42BPB (1-473) protein

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Recombinant MRCKb / CDC42BPB(1-473) protein is supplied in 25 mM HEPES-NaOH pH 7.5, 300 mM NaCl, 10 % glycerol, 0.04 % Triton X-100, 0.5 mM TCEP.

Handhabung: Avoid repeated freeze/thaw cycles,keep on ice when not in storage

Lagerung: -80 °C

Informationen zur Lagerung: Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.

Antigendetails

Target: CDC42BPB (CDC42 Binding Protein Kinase beta (DMPK-Like) (CDC42BPB))

Andere Bezeichnung: MRCKb & CDC42BPB

Hintergrund:

Protein Background: CDC42BPB (CDC42 Binding Protein Kinase Beta) is a serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. This protein regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2. In concert with MYO18A and LURAP1 CDC42BPB is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. In concert with FAM89B/LRAP25 CDC42BPB mediates the targeting of LIMK1 to the lamellipodium resulting in its activation and subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation.

Short Description: Recombinant MRCKb / CDC42BPB(1-473) protein that includes amino acids 1-473 of human MRCKb protein (accession number NP_006026.3) was expressed in a baculovirus expression system, and contains an N-terminal FLAG tag. The molecular weight of the protein is 55.9 kDa.

Aliases: CDC42 Binding Protein Kinase Beta