BMP2 Protein

Produktnummer ABIN7866430

Dieses Recombinant BMP2-Protein wird in Escherichia coli (E. coli) exprimiert.

Kurzübersicht für BMP2 Protein (ABIN7866430)

Target: BMP2 (Bone Morphogenetic Protein 2 (BMP2))

Protein-Typ: Recombinant

Biologische Aktivität: Active

Spezies: Human, Ratte, Maus

Quelle: Escherichia coli (E. coli)

Reinheit: > 95 % by SDS-PAGE

Produktdetails

Verwendungszweck: Recombinant Human BMP-2 Protein

Sequenz: MQAKHKQRKR LKSSCKRHPL YVDFSDVGWN DWIVAPPGYH AFYCHGECPF PLADHLNSTN HAIVQTLVNS VNSKIPKACC VPTELSAISM LYLDENEKVV LKNYQDMVVE GCGCR

Spezifität: Chromosomal location:20p12

Produktmerkmale: Length (aa):115

Endotoxin-Niveau: < 0.1 ng per μg of BMP-2

Anwendungsinformationen

Applikationshinweise: Measured by the ability of BMP-2 to induce alkaline phosphatase production by C2C12 myogenic cells. The ED50 for this effect is typically 0.3-0.8 μg/mL.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: 50 mM acetic acid,The lyophilized BMP-2 is best soluble in 50 mM acetic acid at a concentration of 0.1 mg/mL but should be also soluble in most aqueous buffers when the pH is below 6.0.

Buffer: 50 mM acetic acid

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Lyophilized samples are stable for greater than six months at -20°C to -70°C. Reconstituted BMP-2 should be stored in working aliquots at -20°C. Avoid repeated freeze-thaw cycles!

Haltbarkeit: 6 months

Antigendetails

Target: BMP2 (Bone Morphogenetic Protein 2 (BMP2))

Andere Bezeichnung: BMP-2

Hintergrund:

Synonyms: bone morphogenetic protein 2, BDA2, BMP2A, bone morphogenetic protein 4, ZYME, BMP2B, OFC11, BMP2B1, MCOPS6

Description: Human Bone Morphogenetic Protein-2 (BMP-2) is a disulfide-bonded homodimeric protein with an apparent molecular weight of 26 kDa. BMP-2 regulates similarly to its nearest homologue BMP-4 diverse fundamental processes during embryonic development: BMP-2 and other BMP proteins have great potential for medical therapeutic applications, in particular because they allow or at least accelerate the ossification of extensive bone lesions. The amino acid sequence of recombinant human BMP-2 starts with MQAKHKQ (position 283) containing the Met from the E. coli expression vector. BMP-2 is a heparin binding protein.

Molekulargewicht: 26.0 kDa

Gen-ID: 650

NCBI Accession: NM_001200, NP_001191

UniProt: P12643

Pathways: Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process, Regulation of Muscle Cell Differentiation, Growth Factor Binding, Positive Regulation of fat Cell Differentiation