CLDN18.2 (AA 99-330) protein (Fc Tag)

Produktnummer ABIN7829768

Dieses Recombinant CLDN18.2-Protein wird in HEK-293 Cells produziert.

Kurzübersicht für CLDN18.2 (AA 99-330) protein (Fc Tag) (ABIN7829768)

Target: CLDN18.2

Protein-Typ: Recombinant

Spezies: Cynomolgus

Quelle: HEK-293 Cells

Applikation: Affinity Measurement (AM), Antibody Drug Assay (ADA), Immunoassay (IA), Screening Assay (ScA)

Reinheit: The purity of the protein is greater than 90 % as determined by SDS-PAGE and Coomassie blue staining.

Produktdetails

Proteineigenschaft: AA 99-330

Aufreinigungstag / Konjugat: Fc Tag

Verwendungszweck: Recombinant Cynomolgus CLDN18.2 protein with N-terminal human Fc tag

Spezifität: HFc(Glu99-Ala330) CLDN18.2(Asp28-Gln77)

Produktmerkmale: Extracellular Domain Protein

Anwendungsinformationen

Applikationshinweise: Extracellular Domain Proteins (ECD) can be used as:

• Immunogens for antibody drug development
• Reagents used for CAR-T positive cell monitoring
• Reagents for antibody screening and functional testing
• Reagents for antibody affinity measurement

Kommentare:

The protein was produced using HEK293 mammalian cell secretion expression system to ensure the close-to-native structures and post-translational modifications of the target protein.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Please see Certificate of Analysis for specific instructions of reconstitution.

Buffer: Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Haltbarkeit: 12 months

Antigendetails

Target: CLDN18.2

Hintergrund: SFTA5, SFTPJ
This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is upregulated in patients with ulcerative colitis and highly overexpressed in infiltrating ductal adenocarcinomas. PKC/MAPK/AP-1 (protein kinase C/mitogen-activated protein kinase/activator protein-1) dependent pathway regulates the expression of this gene in gastric cells. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jun 2010]

Molekulargewicht: predicted molecular mass of 31.9 kDa after removal of the signal peptide.