CD38 Protein (AA 44-301) (His tag)

Produktnummer ABIN7829742

Dieses Recombinant CD38-Protein wird in HEK-293 Cells exprimiert.

Kurzübersicht für CD38 Protein (AA 44-301) (His tag) (ABIN7829742)

Target: CD38

Protein-Typ: Recombinant

Spezies: Cynomolgus

Quelle: HEK-293 Cells

Applikation: Affinity Measurement (AM), Antibody Drug Assay (ADA), Immunoassay (IA), Screening Assay (ScA)

Reinheit: The purity of the protein is greater than 85 % as determined by SDS-PAGE and Coomassie blue staining.

Produktdetails

Proteineigenschaft: AA 44-301

Aufreinigungstag / Konjugat: Dieses CD38 Protein ist gelabelt mit His tag.

Verwendungszweck: Recombinant Cynomolgus CD38 protein with N-terminal 10xHis tag

Spezifität: 10xHis tag Cynomolgus CD38(Leu44-Ile301)

Produktmerkmale: Extracellular Domain Protein

Anwendungsinformationen

Applikationshinweise: Extracellular Domain Proteins (ECD) can be used as:

• Immunogens for antibody drug development
• Reagents used for CAR-T positive cell monitoring
• Reagents for antibody screening and functional testing
• Reagents for antibody affinity measurement

Kommentare:

The protein was produced using HEK293 mammalian cell secretion expression system to ensure the close-to-native structures and post-translational modifications of the target protein.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Please see Certificate of Analysis for specific instructions of reconstitution.

Buffer: Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Haltbarkeit: 12 months

Antigendetails

Target: CD38

Hintergrund: ADPRC1, cADPR1, ADPRC 1
The protein encoded by this gene is a non-lineage-restricted, type II transmembrane glycoprotein that synthesizes and hydrolyzes cyclic adenosine 5'-diphosphate-ribose, an intracellular calcium ion mobilizing messenger. The release of soluble protein and the ability of membrane-bound protein to become internalized indicate both extracellular and intracellular functions for the protein. This protein has an N-terminal cytoplasmic tail, a single membrane-spanning domain, and a C-terminal extracellular region with four N-glycosylation sites. Crystal structure analysis demonstrates that the functional molecule is a dimer, with the central portion containing the catalytic site. It is used as a prognostic marker for patients with chronic lymphocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]

Molekulargewicht: predicted molecular mass of 31.2 kDa after removal of the signal peptide.

UniProt: Q5VAN0