CD4 Protein (CD4) (His tag)

Produktnummer ABIN7794645

Dieses Recombinant CD4-Protein wird in HEK-293 Cells produziert.

Kurzübersicht für CD4 Protein (CD4) (His tag) (ABIN7794645)

Target: CD4

Protein-Typ: Recombinant

Spezies: Human

Quelle: HEK-293 Cells

Reinheit: The purity of the protein is greater than 85 % as determined by SDS-PAGE and Coomassie blue staining.

Produktdetails

Aufreinigungstag / Konjugat: Dieses CD4 Protein ist gelabelt mit His tag.

Verwendungszweck: Recombinant human CD4 Protein with C-terminal 6?His tag

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Antigendetails

Target: CD4

Andere Bezeichnung: CD4

Hintergrund: T4, IMD79, Leu-3, OKT4D, CD4mut Background: This gene encodes the CD4 membrane glycoprotein of T lymphocytes. The CD4 antigen acts as a coreceptor with the T-cell receptor on the T lymphocyte to recognize antigens displayed by an antigen presenting cell in the context of class II MHC molecules. The CD4 antigen is also a primary receptor for entry of the human immunodeficiency virus through interactions with the HIV Env gp120 subunit. This gene is expressed not only in T lymphocytes, but also in B cells, macrophages, granulocytes, as well as in various regions of the brain. The protein functions to initiate or augment the early phase of T-cell activation, and may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, May 2020]

Molekulargewicht: Predicted: 42.1 kDa after removal of the signal peptide. The apparent molecular mass of CD4-His is approximately 35-55 kDa due to glycosylation.

UniProt: P01730

Pathways: T-Zell Rezeptor Signalweg, Maintenance of Protein Location, CXCR4-mediated Signaling Events