Prosaposin Protein (PSAP) (His tag)

Produktnummer ABIN7669489

Dieses Recombinant Prosaposin-Protein wird in Escherichia coli (E. coli) produziert.

Kurzübersicht für Prosaposin Protein (PSAP) (His tag) (ABIN7669489)

Target: Prosaposin (PSAP)

Protein-Typ: Recombinant

Biologische Aktivität: Inactive

Spezies: Human

Quelle: Escherichia coli (E. coli)

Reinheit: > 95 %

Produktdetails

Aufreinigungstag / Konjugat: Dieses Prosaposin Protein ist gelabelt mit His tag.

Verwendungszweck: Recombinant Human PSAP protein (His tag)

Sequenz: Gly 17-Asn 524

Aufreinigung: > 95 % as determined by reducing SDS-PAGE.

Sterilität: 0.2 μm filtered

Endotoxin-Niveau: < 10 EU/mg of the protein as determined by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.

Buffer: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % -8 % trehalose, mannitol and 0.01 % Tween 80 are added as protectants before lyophilization.

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Haltbarkeit: 12 months

Antigendetails

Target: Prosaposin (PSAP)

Andere Bezeichnung: PSAP

Hintergrund: This gene encodes a highly conserved preproprotein that is proteolytically processed to generate four main cleavage products including saposins A, B, C, and D. Each domain of the precursor protein is approximately 80 amino acid residues long with nearly identical placement of cysteine residues and glycosylation sites. Saposins A-D localize primarily to the lysosomal compartment where they facilitate the catabolism of glycosphingolipids with short oligosaccharide groups. The precursor protein exists both as a secretory protein and as an integral membrane protein and has neurotrophic activities. Mutations in this gene have been associated with Gaucher disease and metachromatic leukodystrophy. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed.,GLBA,PSAP,SAP1p,proactivator polypeptide,prosaposin

Molekulargewicht:

calculated_mw: 55.8 kDa

observed_mw: 45 kDa

UniProt: P07602

Pathways: Positive Regulation of Endopeptidase Activity