IgG4 Protein

Produktnummer ABIN7668932

Dieses Recombinant IgG4-Protein wird in HEK-293 Cells exprimiert.

Kurzübersicht für IgG4 Protein (ABIN7668932)

Target: IgG4

Protein-Typ: Recombinant

Biologische Aktivität: Inactive

Spezies: Human

Quelle: HEK-293 Cells

Reinheit: > 95 %

Produktdetails

Verwendungszweck: Recombinant Human IgG4-Fc Protein (108 Ser/Pro)

Sequenz: Glu 99-Lys 327, 108Ser/Pro

Aufreinigung: > 95 % as determined by reducing SDS-PAGE.

Sterilität: 0.2 μm filtered

Endotoxin-Niveau: < 1.0 EU per μg of the protein as determined by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween 80 are added as protectants before lyophilization.

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Haltbarkeit: 12 months

Antigendetails

Target: IgG4

Substanzklasse: Antibody

Hintergrund: SCN3B (sodium channel, voltage-gated, type III, beta ,human IgG1-Fc chimera) belongs to the sodium channel auxiliary subunit SCN3B family. It contains 1 Ig-like C2-type (immunoglobulin-like) domain. Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit and one or more regulatory beta subunits. They are responsible for the generation and propagation of action potentials in neurons and muscle. SCN3B gene encodes one member of the sodium channel beta subunit gene family, and influences the inactivation kinetics of the sodium channel. Two alternatively spliced variants, encoding the same protein, have been identified. Defects in SCN3B are the cause of Brugada syndrome type 7. A tachyarrhythmia characterized by right bundle branch block and ST segment elevation on an electrocardiogram. It can cause the ventricles to beat so fast that the blood is prevented from circulating efficiently in the body. When this situation occurs (called ventricular fibrillation), the individual will faint and may die in a few minutes if the heart is not reset.,IGHG4,Ig gamma-4 chain C region,IgG4 Fc

Molekulargewicht:

calculated_mw: 25.5 kDa

observed_mw: 35 kDa

UniProt: P01861