beta-2 Microglobulin Protein (His tag)

Produktnummer ABIN7668229

Dieses Recombinant beta-2 Microglobulin-Protein wird in HEK-293 Cells produziert.

Kurzübersicht für beta-2 Microglobulin Protein (His tag) (ABIN7668229)

Target: beta-2 Microglobulin (B2M) (beta-2-Microglobulin (B2M))

Protein-Typ: Recombinant

Biologische Aktivität: Inactive

Spezies: Human

Quelle: HEK-293 Cells

Reinheit: > 97 %

Produktdetails

Aufreinigungstag / Konjugat: Dieses beta-2 Microglobulin Protein ist gelabelt mit His tag.

Verwendungszweck: Recombinant Human Beta-2-Microglobulin/B2M Protein (HEK293 Cells, His Tag)

Sequenz: Met 1-Met 119

Aufreinigung: > 97 % as determined by reducing SDS-PAGE.

Sterilität: 0.2 μm filtered

Endotoxin-Niveau: < 1.0 EU per μg of the protein as determined by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween 80 are added as protectants before lyophilization.

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Haltbarkeit: 12 months

Antigendetails

Target: beta-2 Microglobulin (B2M) (beta-2-Microglobulin (B2M))

Andere Bezeichnung: Beta-2-Microglobulin

Hintergrund: B2M, also known as β2-Microglobulin or CDABP0092, is a component of MHC class I molecules found expression in all nucleated cells (excludes red blood cells). The major function of MHC class I moleculesis is to display fragments of proteins from within the cell to T-cells and cells containing foreign proteins will be attacked. B2M(β2-Microglobulin) is a low molecular weight protein. It was demonstrated that B2M(β2-Microglobulin) was localized in the membranes of nucleated cells and was found to be associated with HL-A antigens.B2M(β2- Microglobulin) is present in free form in various body fluids and as a subunit of histocompatibility antigens on cell surfaces lateral to theα3 chain. Unlikeα3, β2 has no transmembrane region. Directly above β2 lies the α1 chain, which itself is lateral to the α2. In the absence of B2M(β2 microglobulin), very limited amounts of MHC class I (classical and non-classical) molecules can be detected on the surface. In the absence of MHC class I, CD8 T cells, a subset of T cells involved in the development of acquired immunity cannot develop. Low levels of B2M(β2 microglobulin) can indicate non-progression of HIV.,B2M;Beta-2-Microglobulin;β2-Microglobulin

Molekulargewicht:

calculated_mw: 13.5 kDa

observed_mw: 13.5 kDa

UniProt: P61769

Pathways: T-Zell Rezeptor Signalweg, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process