AMH Protein (AA 447-554) (His-TRX)

Produktnummer ABIN7668182

Dieses Recombinant AMH-Protein wird in Escherichia coli (E. coli) exprimiert.

Kurzübersicht für AMH Protein (AA 447-554) (His-TRX) (ABIN7668182)

Target: AMH (Anti-Mullerian Hormone (AMH))

Protein-Typ: Recombinant

Biologische Aktivität: Inactive

Spezies: Maus

Quelle: Escherichia coli (E. coli)

Reinheit: > 95 %

Produktdetails

Proteineigenschaft: AA 447-554

Aufreinigungstag / Konjugat: Dieses AMH Protein ist gelabelt mit His-TRX.

Verwendungszweck: Recombinant Mouse AMH protein (TRX,His tag)

Sequenz: Ser447-Val554

Aufreinigung: > 95 % as determined by reducing SDS-PAGE.

Sterilität: 0.2 μm filtered

Endotoxin-Niveau: < 10 EU/mg of the protein as determined by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.

Buffer: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % -8 % trehalose, mannitol and 0.01 % Tween 80 are added as protectants before lyophilization.

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Haltbarkeit: 12 months

Antigendetails

Target: AMH (Anti-Mullerian Hormone (AMH))

Andere Bezeichnung: AMH

Hintergrund: Anti-Mullerian hormone (AMH), a member of the TGF-beta superfamily, is produced by granulosa cells (GCs) of preantral and small antral follicles and plays a role in regulating the recruitment of primordial follicles and the FSH-dependent development of follicles. BMP15 up-regulates the transcription of AMH and that the inhibition of p38 MAPK decreases the BMP15-induced expression of AMH and SOX9, suggesting that BMP15 up-regulates the expression of AMH via the p38 MAPK signaling pathway, and this process involves the SOX9 transcription factor. AMH is widely used for assessing ovarian reserve, and it is particularly convenient, because it is thought to have minimal variability throughout the menstrual cycle. Fetal anti-Mullerian hormone (AMH) is responsible for normal male sexual differentiation, and circulating AMH is used as a marker of testicular tissue in newborns with disorders of sex development. Anti-Mullerian hormone (AMH) produced in the developing testis induces the regression of the Mullerian duct, which develops into the oviducts, uterus and upper vagina. As well as other hormone receptors, and a decreased ovarian cortex cell proliferation. These results help understand the inhibitory effects of AMH on follicular development.,Amh,Anti-Muellerian hormone,Muellerian-inhibiting factor,Muellerian-inhibiting substance

Molekulargewicht:

calculated_mw: 31.8 kDa

observed_mw: 35 kDa

UniProt: P27106

Pathways: Negative Regulation of Hormone Secretion