DKK3 Protein (AA 22-350) (Fc Tag)

Produktnummer ABIN7597408

Produktdetails

Target: DKK3

Protein-Typ: Recombinant

Proteineigenschaft: AA 22-350

Spezies: Human

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses DKK3 Protein ist gelabelt mit Fc Tag.

Verwendungszweck: Recombinant human DKK3 Protein with C-terminal human Fc tag

Sequenz: DKK3(Ala22-Ile350) hFc(Glu99-Ala330)

Reinheit: The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.

Anwendungsinformationen

Applikationshinweise: Extracellular Domain Proteins (ECD) can be used as:

• Immunogens for antibody drug development
• Reagents used for CAR-T positive cell monitoring
• Reagents for antibody screening and functional testing
• Reagents for antibody affinity measurement

Kommentare:

The protein was made using HEK293 mammalian cell secretion expression system to ensure the close-to-native structures and post-translational modifications of the target protein.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4. Normally 5 % – 8% trehalose is added as protectants before lyophilization.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Haltbarkeit: 12 months

Antigendetails

Target: DKK3

Abstract: DKK3 Produkte

Hintergrund: RIG, CRRL, REIC
This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. The expression of this gene is decreased in a variety of cancer cell lines and it may function as a tumor suppressor gene. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]

Molekulargewicht: predicted molecular mass of 62.4 kDa after removal of the signal peptide. The apparent molecular mass of DKK3-hFc is 70-130 kDa due to glycosylation.

UniProt: Q9UBP4