CCR6 Protein (DYKDDDDK Tag)

Produktnummer ABIN7597217

Dieses MNP Membrane Nanoparticle CCR6-Protein wird in HEK-293 Cells exprimiert.

Kurzübersicht für CCR6 Protein (DYKDDDDK Tag) (ABIN7597217)

Target: CCR6 (Chemokine (C-C Motif) Receptor 6 (CCR6))

Protein-Typ: MNP Membrane Nanoparticle

Spezies: Human

Quelle: HEK-293 Cells

Produktdetails

Aufreinigungstag / Konjugat: Dieses CCR6 Protein ist gelabelt mit DYKDDDDK Tag.

Verwendungszweck: Human CCR6 full length protein-MNP

Produktmerkmale: Plasma membrane-coated nanoparticles (MNPs) have been used in various applications, including delivery of therapeutic agents and induction of immune responses et al. Unlike the conventional strategies, MNPs directly leverage intact and natural functions of cell membranes, and show high biocompatibility, specificity, and low side effects. Our optimized MNPs platform for the full-length membrane protein production uses membrane coating technology and a HEK293 based expression platform. The high-purity plasma membrane-coated nanoparticles were produced by extrusion after membrane extraction from the host HEK293 cells containing the overexpressed target proteins.

Anwendungsinformationen

Kommentare:

Advantages of MNP:

• High display density of target membrane proteins
• Native structure and orientation of transmembrane protein
• soluble in aqueous solutions for routine biochemical analysis
• Detergent-free purification process
• Strong immunogenicity
• Works for MPs that can´t be produced via VLPs and EXos

Limitations of MNP:

• Lack of accurate quantification of the target membrane proteins.
• Need to develop special SPR assayx.
• Cell membranes contain housekeeping proteins that can result in immune response dilution.
• Some membrane proteins can´t be enriched on membrane.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: Lyophilized from PBS. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Haltbarkeit: 12 months

Antigendetails

Target: CCR6 (Chemokine (C-C Motif) Receptor 6 (CCR6))

Andere Bezeichnung: CCR6

Hintergrund: BN-1, C-C CKR-6, CC-CKR-6, CCR-6, CD196, CKR-L3, CKRL3, CMKBR6, DCR2, DRY6, GPR29, GPRCY4, STRL22
The protein is a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. The gene is preferentially expressed by immature dendritic cells and memory T cells. The ligand of this receptor is macrophage inflammatory protein 3 alpha (MIP-3 alpha). This receptor has been shown to be important for B-lineage maturation and antigen-driven B-cell differentiation, and it may regulate the migration and recruitment of dentritic and T cells during inflammatory and immunological responses. Alternatively spliced transcript variants that encode the same protein have been described for this gene.

Molekulargewicht: The human full length CCR6 protein has a MW of 42.5 kDa

UniProt: P51684

Pathways: cAMP Metabolic Process