Dendrotoxin-K Protein

Produktnummer ABIN7582326

Dieses Native Dendrotoxin-K-Protein wird in Snake (Serpentes) exprimiert.

Kurzübersicht für Dendrotoxin-K Protein (ABIN7582326)

Target: Dendrotoxin-K

Protein-Typ: Native

Spezies: Dendraspis polylepis polylepis

Quelle: Snake (Serpentes)

Applikation: Blocking Peptide (BP)

Reinheit: ≥99 % (HPLC)

Produktdetails

Verwendungszweck: A Potent Blocker of KV1.1 and KV1.2 Channels

Sequenz: AAKYCKLPLR IGPCKRKIPS FYYKWKAKQC LPFDYSGCGG NANRFKTIEE CRRTCVG-OH

Spezifität: Toxin target: KV1.1, Kv1.1-containing heterooligomer.,
Disulfide bonds between: Cys5-Cys55, Cys14-Cys38, and Cys30-Cys51

Produktmerkmale: A Potent Blocker of KV1.1 and KV1.2 Channels

Anwendungsinformationen

Applikationshinweise: Antigen Preadsorption Control: 100 nM

Kommentare:

Electrophysiology

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Centrifuge the vial (10,000 x g for 5 minutes) before adding solvent to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Gently tap, tilt, and roll the vial to aid dissolution. Avoid vigorous vortexing, light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 μM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20 °C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.

Buffer: Lyophilized from double distilled water (ddH2O). May contain TFA as a residual counter ion.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.,The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

Antigendetails

Target: Dendrotoxin-K

Hintergrund: Venom basic protease inhibitor K, DTX-K,Dendrotoxin-K is isolated from Dendroaspis p.polylepis snake venom by modification of the procedure of Schweitz1 and purified to homogeneity. It blocks mainly KV1.1 (EC50=0.6 nM2) and Kv1.1-containing heterooligomer.

Molekulargewicht: 6560 Da

UniProt: P00981