GFRAL Protein (AA 19-351) (Fc Tag)

Produktnummer ABIN7566159

Produktdetails

Target: GFRAL (GDNF Family Receptor alpha Like (GFRAL))

Protein-Typ: Recombinant

Biologische Aktivität: Active

Proteineigenschaft: AA 19-351

Spezies: Human

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses GFRAL Protein ist gelabelt mit Fc Tag.

Verwendungszweck: GFRAL (human):Fc (human) (rec.)

Kreuzreaktivität: Human

Produktmerkmale: The extracellular domain of human GFRAL (aa 19-351) is fused to the N-terminus of the Fc region of human IgG1.

Reinheit: >98 % (SDS-PAGE)

Sterilität: Sterile filtered

Endotoxin-Niveau: <1EU/mg purified protein (LAL test, Lonza).

Biological Activity Comment: Measured by its binding ability in a functional ELISA.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: Lyophilized from 0.2μm-filtered solution in PBS.

Handhabung: Avoid freeze/thaw cycles.Centrifuge lyophilized vial before opening and reconstitution.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung:

Short Term Storage: +4°C

Long Term Storage: -20°C

Use & Stability: Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.

Antigendetails

Target: GFRAL (GDNF Family Receptor alpha Like (GFRAL))

Andere Bezeichnung: GFRAL (GFRAL Produkte)

Hintergrund:

GDNF Family Receptor alpha-like, Gral, Glial Cellline-derived Neurotrophic Factor Receptor alpha-like, GFR alpha-like, C6orf144

GFRAL (GDNF receptor alpha-like) is a distant member of the GDNFR family of proteins. Human GFR alpha-like contains a 333aa extracellular domain, a 20aa transmembrane domain and a 23aa cytoplasmic domain. Over the extracellular domain, human GFRAL shares 72 % and 71 % identity with mouse and rat GFRAL, respectively. It is expressed on both fetal and adult hindbrain neurons of the CNS and functions as an anti-apoptotic molecule during neuronal stress. GFRAL is a functional receptor for GDF15, facilitating weight-loss functions of the protein through c-Ret downstream signaling. GFRAL and GDF15 signaling is implicated in diet-based obesity and insulin resistance.

Molekulargewicht: ~50-100kDa

NCBI Accession: NP_997293