CD38 Protein (Fc Tag)

Produktnummer ABIN7566111

Dieses Recombinant CD38-Protein wird in HEK-293 Cells exprimiert.

Kurzübersicht für CD38 Protein (Fc Tag) (ABIN7566111)

Target: CD38

Protein-Typ: Recombinant

Spezies: Human

Quelle: HEK-293 Cells

Reinheit: >98 % (SDS-PAGE)

Produktdetails

Aufreinigungstag / Konjugat: Dieses CD38 Protein ist gelabelt mit Fc Tag.

Verwendungszweck: CD38 (human):Fc (mouse) (rec.)

Kreuzreaktivität: Human

Produktmerkmale: The extracellular domain of human CD38 (aa 43 - 300) is fused to the N-terminus of the Fc region of mouse IgG2a.

Sterilität: Sterile filtered

Endotoxin-Niveau: <1EU/mg protein (LAL test, Lonza).

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: Lyophilized from 0.2μm-filtered solution in PBS.

Handhabung: Avoid freeze/thaw cycles.Centrifuge lyophilized vial before opening and reconstitution.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung:

Short Term Storage: +4°C

Long Term Storage: -20°C

Use & Stability: Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.

Antigendetails

Target: CD38

Hintergrund:

ADP-ribosyl cyclase 1, cyclic ADP-ribose hydrolase 1, ADPRC 1, T10

CD38, also known as cyclic ADP ribose hydrolase is a glycoprotein found on the surface of many immune cells (white blood cells), including CD4+, CD8+, B lymphocytes and natural killer cells. CD38 also functions in cell adhesion, signal transduction and calcium signaling.CD38 is a multifunctional ectoenzyme that catalyzes the synthesis and hydrolysis of cyclic ADP-ribose (cADPR) from NAD+ to ADP-ribose. These reaction products are essential for the regulation of intracellular Ca2+. The loss of CD38 function is associated with impaired immune responses, metabolic disturbances, and behavioral modifications including social amnesia possibly related to autism. The CD38 protein is a marker of cell activation. It has been connected to HIV infection, leukemias, myelomas, solid tumors, type II diabetes mellitus and bone metabolism, as well as some genetically determined conditions.

Molekulargewicht: ~50-70kDa (SDS-PAGE)

UniProt: P28907