GPR52 Protein (AA 1-361) (His tag)

Produktnummer ABIN7562795

Dieses Recombinant GPR52-Protein wird in HEK-293 Cells exprimiert.

Kurzübersicht für GPR52 Protein (AA 1-361) (His tag) (ABIN7562795)

Target: GPR52 (G Protein-Coupled Receptor 52 (GPR52))

Protein-Typ: Recombinant

Spezies: Maus

Quelle: HEK-293 Cells

Reinheit: > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)

Güteklasse: custom-made

Produktdetails

Proteineigenschaft: AA 1-361

Aufreinigungstag / Konjugat: Dieses GPR52 Protein ist gelabelt mit His tag.

Verwendungszweck: Predefined custom protein recombinant Gpr52 Protein expressed in mammalian cells.

Sequenz: MNESRWTEWR ILNMSSSIVN VSEHHSCPLG FGHYSVEDVC IFETVVIVLL TFLIISGNLT VIFVFHCAPL LHHYTTSYFI QTMAYADLLV GVTCLVPTLS LLHYSTGVHE SLTCQVFGYI ISVLKSVSMA CLACISVDRY LAITKPLSYN QLVTPCRLRI CIIMIWIYSC LIFLPSFFGW GKPGYHGDIF EWCATSWLTS AYFTCFIVCL LYAPAALVVC FTYFHIFKIC RQHTKEINDR RARFPSHEVE ASREAGHSPD RRYAMVLFRI TSVFYMLWLP YIIYFLLESS RVLDNPTLSF LTTWLAISNS FCNCVIYSLS NSVFRLGLRR LSETMCTSCV CAKDQEAQDP KPRRRANSCS I Sequence without tag. The proposed Strep-Tag is based on experience with the expression system. Our team may suggest an additional tag depending on the complexity of the protein. If you have a special request, please contact us.

Spezifität: If you are looking for a specific domain and are interested in a partial protein or a different isoform, please contact us regarding an individual offer.

Produktmerkmale: Key Benefits:

• Predefined custom protein - from design to production - by highly experienced protein experts.
• Protein expressed in mammalian cells and purified in one-step affinity chromatography
• The optimized expression system ensures reliability for intracellular, secreted and transmembrane proteins.
• State-of-the-art algorithm used for plasmid design (Gene synthesis).

This protein is a predefined protein and will be made for the first time for your order. Our experts in the lab try to ensure that you receive soluble protein.

If you are not interested in a full length protein, please contact us for individual protein fragments.

The big advantage of ordering our predefined custom proteins in comparison to ordering custom-made proteins from other companies is that there is no financial obligation in case the protein cannot be expressed or purified.

Anwendungsinformationen

Applikationshinweise: We expect the protein to work for functional studies. As the protein has not been tested for functional studies yet we cannot offer a guarantee though.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: The buffer composition is at the discretion of the manufacturer.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -80 °C

Informationen zur Lagerung: Store at -80°C.

Haltbarkeit: 12 months

Antigendetails

Target: GPR52 (G Protein-Coupled Receptor 52 (GPR52))

Andere Bezeichnung: Gpr52

Hintergrund: G-protein coupled receptor 52,FUNCTION: G- protein coupled receptor activated by antipsychotics reserpine leading to an increase in intracellular cAMP and its internalization (By similarity). May play a role in locomotor activity through modulation of dopamine, NMDA and ADORA2A-induced locomotor activity. These behavioral changes are accompanied by modulation of the dopamine receptor signaling pathway in striatum (PubMed:24587241, PubMed:28583861). Modulates HTT level via cAMP-dependent but PKA independent mechanisms throught activation of RAB39B that translocates HTT to the endoplasmic reticulum, thus avoiding proteasome degradation (PubMed:25738228). {ECO:0000250|UniProtKB:Q9Y2T5, ECO:0000269|PubMed:24587241, ECO:0000269|PubMed:25738228, ECO:0000269|PubMed:28583861}.

Molekulargewicht: 41.3 kDa

UniProt: P0C5J4

AlphaFold: P0C5J4