SLC22A17 Protein (AA 1-401) (His tag)

Produktnummer ABIN7561166

Produktdetails

Target: SLC22A17 (Solute Carrier Family 22 (Organic Cation Transporter), Member 17 (SLC22A17))

Protein-Typ: Recombinant

Proteineigenschaft: AA 1-401

Spezies: Maus

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses SLC22A17 Protein ist gelabelt mit His tag.

Verwendungszweck: Custom-made recombinant Slc22a17 Protein expressed in mammalian cells.

Sequenz: MPSARFGRRG IVLLTLGLVG PCGVGGAAAG SSTGIMALRF LLGFLLAGVD LGVYLMRLEL CDPTQRLRVA LAGELVGVGG HFLFLGLALV SKDWRFLQRM ITAPCILFLF YGWPGLFLES ARWLIVKRQI EEAQSVLRIL AERNRPHGQM LGEEAQEALQ ELENTCPLPA TSTFSFASLL NYRNIWKNLL ILGFTNFIAH AIRHCYQPVG GGGSPSDFYL CSLLASGTAA LACVFLGVTV DRFGRRGILL LSMTLTGIAS LVLLGLWDYL NDAAITTFSV LGLFSSQASA ILSTLLASEV IPTTVRGRGL GLIMALGALG GLSCPAQRLH MGHGAFLQHV VLAACALLCI LSIMLLPETK RKLLPEVLRD GELCRRPSLL RQPPPNRCDH VPLLATPNPA L Sequence without tag. The proposed Purification-Tag is based on experiences with the expression system, a different complexity of the protein could make another tag necessary. In case you have a special request, please contact us.

Spezifität: If you are looking for a specific domain and are interested in a partial protein or a different isoform, please contact us regarding an individual offer.

Produktmerkmale: Key Benefits:

• Made to order protein - from design to production - by highly experienced protein experts.
• Protein expressed in mammalian cells and purified in one-step affinity chromatography
• The optimized expression system ensures reliability for intracellular, secreted and transmembrane proteins.
• State-of-the-art algorithm used for plasmid design (Gene synthesis).

This protein is a made-to-order protein and will be made for the first time for your order. Our experts in the lab try to ensure that you receive soluble protein.

If you are not interested in a full length protein, please contact us for individual protein fragments.

The big advantage of ordering our made-to-order proteins in comparison to ordering custom made proteins from other companies is that there is no financial obligation in case the protein cannot be expressed or purified.

Reinheit: > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)

Güteklasse: custom-made

Anwendungsinformationen

Applikationshinweise: We expect the protein to work for functional studies. As the protein has not been tested for functional studies yet we cannot offer a guarantee though.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: The buffer composition is at the discretion of the manufacturer.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -80 °C

Informationen zur Lagerung: Store at -80°C.

Haltbarkeit: 12 months

Antigendetails

Target: SLC22A17 (Solute Carrier Family 22 (Organic Cation Transporter), Member 17 (SLC22A17))

Andere Bezeichnung: Slc22a17 (SLC22A17 Produkte)

Hintergrund: Solute carrier family 22 member 17 (24p3 receptor) (24p3R) (Brain-type organic cation transporter) (Lipocalin-2 receptor),FUNCTION: Cell surface receptor for LCN2 (24p3) that plays a key role in iron homeostasis and transport. Able to bind iron-bound LCN2 (holo-24p3), followed by internalization of holo-24p3 and release of iron, thereby increasing intracellular iron concentration and leading to inhibition of apoptosis. Also binds iron-free LCN2 (apo-24p3), followed by internalization of apo-24p3 and its association with an intracellular siderophore, leading to iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration and resulting in apoptosis. {ECO:0000269|PubMed:16377569}.

Molekulargewicht: 43.2 kDa

UniProt: Q9D9E0

AlphaFold: Q9D9E0

Pathways: Transition Metal Ion Homeostasis