AQP11 Protein (AA 1-271) (His tag)

Produktnummer ABIN7558637

Produktdetails

Target: AQP11 (Aquaporin 11 (AQP11))

Protein-Typ: Recombinant

Proteineigenschaft: AA 1-271

Spezies: Maus

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses AQP11 Protein ist gelabelt mit His tag.

Verwendungszweck: Custom-made recombinant Aqp11 Protein expressed in mammalian cells.

Sequenz: MSALLGLRPE VQDTCISLGL MLLFVLFVGL ARVIARQQLH RPVVHAFVLE FLATFQLCCC THELQVLSEQ DSAHPTWTLT LIYFFSLVHG LTLVGTASNP CGVMMQMILG GMSPEMGAVR LLAQLVSALC SRYCISALWS LSLTKYHYDE RILACRNPIH TDMSKAIIIE AICSFIFHSA LLHFQEVRTK LRIHLLAALI TFLAYAGGSL TGALFNPALA LSLHFPCFDE LFYKFFVVYW LAPSVGVLMM ILMFSFFLPW LHNNQMTNKK E Sequence without tag. The proposed Purification-Tag is based on experiences with the expression system, a different complexity of the protein could make another tag necessary. In case you have a special request, please contact us.

Spezifität: If you are looking for a specific domain and are interested in a partial protein or a different isoform, please contact us regarding an individual offer.

Produktmerkmale: Key Benefits:

• Made to order protein - from design to production - by highly experienced protein experts.
• Protein expressed in mammalian cells and purified in one-step affinity chromatography
• The optimized expression system ensures reliability for intracellular, secreted and transmembrane proteins.
• State-of-the-art algorithm used for plasmid design (Gene synthesis).

This protein is a made-to-order protein and will be made for the first time for your order. Our experts in the lab try to ensure that you receive soluble protein.

If you are not interested in a full length protein, please contact us for individual protein fragments.

The big advantage of ordering our made-to-order proteins in comparison to ordering custom made proteins from other companies is that there is no financial obligation in case the protein cannot be expressed or purified.

Reinheit: > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)

Güteklasse: custom-made

Anwendungsinformationen

Applikationshinweise: We expect the protein to work for functional studies. As the protein has not been tested for functional studies yet we cannot offer a guarantee though.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: The buffer composition is at the discretion of the manufacturer.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -80 °C

Informationen zur Lagerung: Store at -80°C.

Haltbarkeit: 12 months

Antigendetails

Target: AQP11 (Aquaporin 11 (AQP11))

Andere Bezeichnung: Aqp11 (AQP11 Produkte)

Hintergrund: Aquaporin-11 (AQP-11),FUNCTION: Channel protein that facilitates the transport of water, glycerol and hydrogen peroxide across membrane of cell or organelles guaranteeing intracellular homeostasis in several organes like liver, kidney and brain (PubMed:21118806, PubMed:21251984). In situation of stress, participates in endoplasmic reticulum (ER) homeostasis by regulating redox homeostasis through the transport of hydrogen peroxide across the endoplasmic reticulum membrane thereby regulating the oxidative stress through the NADPH oxidase 2 pathway (PubMed:23275615, PubMed:30656220). Plays a role by maintaining an environment suitable for translation or protein foldings in the ER lumen namely by participating in the PKD1 glycosylation processing resulting in regulation of PKD1 membrane trafficking thereby preventing the accumulation of unfolding protein in ER (PubMed:24854278, PubMed:18606867). Plays a role in the proximal tubule function by regulating its endosomal acidification (PubMed:16107722). May play a role in postnatal kidney development (PubMed:18701606, PubMed:23486012, PubMed:27582095). {ECO:0000269|PubMed:16107722, ECO:0000269|PubMed:18606867, ECO:0000269|PubMed:18701606, ECO:0000269|PubMed:21118806, ECO:0000269|PubMed:21251984, ECO:0000269|PubMed:23275615, ECO:0000269|PubMed:23486012, ECO:0000269|PubMed:24854278, ECO:0000269|PubMed:27582095, ECO:0000269|PubMed:30656220}.

Molekulargewicht: 30.5 kDa

UniProt: Q8BHH1