HRG Protein (His tag)

Produktnummer ABIN7536456

Produktdetails

Target: HRG (Histidine-Rich Glycoprotein (HRG))

Protein-Typ: Recombinant

Spezies: Human

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses HRG Protein ist gelabelt mit His tag.

Verwendungszweck: Recombinant Human HRG/HPRG Protein

Sequenz: VSPTDCSAVE PEAEKALDLI NKRRRDGYLF QLLRIADAHL DRVENTTVYY LVLDVQESDC SVLSRKYWND CEPPDSRRPS EIVIGQCKVI ATRHSHESQD LRVIDFNCTT SSVSSALANT KDSPVLIDFF EDTERYRKQA NKALEKYKEE NDDFASFRVD RIERVARVRG GEGTGYFVDF SVRNCPRHHF PRHPNVFGFC RADLFYDVEA LDLESPKNLV INCEVFDPQE HENINGVPPH LGHPFHWGGH ERSSTTKPPF KPHGSRDHHH PHKPHEHGPP PPPDERDHSH GPPLPQGPPP LLPMSCSSCQ HATFGTNGAQ RHSHNNNSSD LHPHKHHSHE QHPHGHHPHA HHPHEHDTHR QHPHGHHPHG HHPHGHHPHG HHPHGHHPHC HDFQDYGPCD PPPHNQGHCC HGHGPPPGHL RRRGPGKGPR PFHCRQIGSV YRLPPLRKGE VLPLPEANFP SFPLPHHKHP LKPDNQPFPQ SVSESCPGKF KSGFPQVSMF FTHTFPK

Spezifität: Val19-Lys525

Reinheit: > 95 % by SDS-PAGE.

Sterilität: 0.22 μm filtered

Endotoxin-Niveau: <0.001 EU/μg

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Centrifuge the vial before opening. Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water. Avoid votex or vigorously pipetting the protein. For long term storage, it is recommended to add a carrier protein or stablizer (e.g. 0.1 % BSA, 5 % HSA, 10 % FBS or 5 % Trehalose), and aliquot the reconstituted protein solution to minimize free-thaw cycles.

Konzentration: 0.82 mg/mL

Buffer: Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Store the lyophilized protein at -20°C to -80°C for 12 months.|After reconstitution, the protein solution is stable at -20°C for 3 months, at 2-8°C for up to 1 week.

Antigendetails

Target: HRG (Histidine-Rich Glycoprotein (HRG))

Andere Bezeichnung: HRG/HPRG (HRG Produkte)

Synonyme: AI265597 Protein, AW413091 Protein, D16jh2 Protein, D18020 Protein, Hprg Protein, Hrgp Protein, HPRG Protein, HRGP Protein, THPH11 Protein, HRG1 Protein, histidine rich glycoprotein Protein, histidine-rich glycoprotein Protein, HRG Protein, LOAG_12427 Protein, LOC100597044 Protein, Hrg Protein

Hintergrund:

Description: Histidine-rich glycoprotein, also known as HRG and HPRG, is a glycoprotein located in plasma and platelets and contains an unusually large amount of histidine and proline.The specific functions of HRG remain unclear, but it is known that the protein binds heme, dyes, and divalent metal ions. It inhibits rosette formation and interacts with heparin, thrombospondin, and plasminogen. Two of the protein's effects, the inhibition of fibrinolysis, and the reduction of inhibition of coagulation indicate a potential prothrombotic effect. HPRG is evolutionarily, functionally, and structurally related to cleaved high molecular weight kininogen (HKa), an anti-angiogenic polypeptide that stimulates apoptosis of proliferating endothelial cells through binding to cell-surface tropomyosin. The antiangiogenic activity of the multidomain plasma protein HPRG is localized to its histidine-proline-rich (H/P) domain and has recently been shown to be mediated, at least partially, through binding to cell-surface tropomyosin in fibroblast growth factor-2-activated endothelial cells.

Name: HPRG, HRGP, THPH11,HRG

Gen-ID: 3273

UniProt: P04196