CD47 Protein (CD47) (Fc Tag)

Produktnummer ABIN7536134

Dieses Recombinant CD47-Protein wird in HEK-293 Cells produziert.

Kurzübersicht für CD47 Protein (CD47) (Fc Tag) (ABIN7536134)

Target: CD47

Protein-Typ: Recombinant

Biologische Aktivität: Active

Spezies: Ratte

Quelle: HEK-293 Cells

Reinheit: > 97 % by SDS-PAGE.

Produktdetails

Aufreinigungstag / Konjugat: Dieses CD47 Protein ist gelabelt mit Fc Tag.

Verwendungszweck: Active Recombinant Rat CD47 Protein

Sequenz: QLLLSKVKSV EFTSCNDTVV IPCKVLNVEA QSTDEMFVKW KLNKSYIFIY DGNKNSTTRE QNFTSAKISV SDLLKGIASL TMDTHEAVVG NYTCEVTELS REGKTVIELK NRPVSWFSTN EK

Spezifität: Gln 19 - Lys 140

Sterilität: 0.22 μm filtered

Endotoxin-Niveau: <0.1EU/μg

Biological Activity Comment: Measured by its binding ability in a functional ELISA.Immobilized Human CD172a at 2 μg/mL (100 μL/well) can bind Human CD47 with a linear range of 19.5-3491.5ng/mL.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Centrifuge the vial before opening. Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water. Avoid votex or vigorously pipetting the protein. For long term storage, it is recommended to add a carrier protein or stablizer (e.g. 0.1 % BSA, 5 % HSA, 10 % FBS or 5 % Trehalose), and aliquot the reconstituted protein solution to minimize free-thaw cycles.

Buffer: Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Store the lyophilized protein at -20°C to -80°C for 12 months.|After reconstitution, the protein solution is stable at -20°C for 3 months, at 2-8°C for up to 1 week.

Antigendetails

Target: CD47

Andere Bezeichnung: CD47

Hintergrund:

Description: CD47 contains 1 Ig-like V-type (immunoglobulin-like) domain and is a receptor for the C-terminal cell binding domain of thrombospondin. It may play a role in membrane transport and signal transduction. CD47 is also a membrane protein, which is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular matrix. It is very broadly distributed on normal adult tissues, as well as ovarian tumors, being especially abundant in some epithelia and the brain. CD47 may play a role in membrane transport and/or integrin dependent signal transduction. It may prevent premature elimination of red blood cells. It also may be involved in membrane permeability changes induced following virus infection. By acting as an adhesion receptor for THBS1 on platelets, CD47 plays a role in both cell adhesion and in the modulation of integrins. It also plays an important role in memory formation and synaptic plasticity in the hippocampus.

Name: Itgp,CD47

Gen-ID: 29364

UniProt: P97829