Fibronectin Protein (AA 32-230) (GST-His-Tag)

Produktnummer ABIN7505313

Recombinant Fibronectin-Protein exprimiert in Escherichia coli (E. coli).

Kurzübersicht für Fibronectin Protein (AA 32-230) (GST-His-Tag) (ABIN7505313)

Target: Fibronectin

Protein-Typ: Recombinant

Spezies: Human

Quelle: Escherichia coli (E. coli)

Reinheit: > 95 % as determined by reducing SDS-PAGE.

Produktdetails

Proteineigenschaft: AA 32-230

Aufreinigungstag / Konjugat: Dieses Fibronectin Protein ist gelabelt mit GST-His-Tag.

Sequenz: Gln 32-Arg 230

Produktmerkmale: A DNA sequence encoding the Human Fibronectin protein (P02751) (Gln 32-Arg 230) was expressed with a N-GST&C-His tag.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization.

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Haltbarkeit: 12 months

Antigendetails

Target: Fibronectin

Hintergrund:

Abbreviation: Fibronectin

Target Synonym: Fibronectin,FN1,CIG,ED-B,FINC,FN,FNZ,GFND,GFND2,LETS,MSF

Background: Fibronectin is a high-molecular weight glycoprotein of the extracellular matrix that binds to membrane-spanning receptor proteins called integrins. Similar to integrins, fibronectin binds extracellular matrix components such as collagen, fibrin, and heparan sulfate proteoglycans. Fibronectin plays a major role in cell adhesion, growth, migration, and differentiation, and it is important for processes such as wound healing and embryonic development. Altered fibronectin expression, degradation, and organization has been associated with a number of pathologies, including cancer and fibrosis. Anastellin binds fibronectin and induces fibril formation. This fibronectin polymer, named superfibronectin, exhibits enhanced adhesive properties. Both anastellin and superfibronectin inhibit tumor growth, angiogenesis and metastasis. Anastellin activates p38 MAPK and inhibits lysophospholipid signaling.

Molekulargewicht:

Calculated MW: 46.78 kDa

Observed MW: 50 kDa

UniProt: P02751