Tspan-8 Protein (His tag)

Produktnummer ABIN7488814

Recombinant Tspan-8-Protein exprimiert in HEK-293 Cells.

Kurzübersicht für Tspan-8 Protein (His tag) (ABIN7488814)

Target: Tspan-8 (TSPAN8) (Tetraspanin 8 (TSPAN8))

Protein-Typ: Recombinant

Spezies: Maus

Quelle: HEK-293 Cells

Reinheit: 90 %

Güteklasse: MALS verified

Produktdetails

Aufreinigungstag / Konjugat: Dieses Tspan-8 Protein ist gelabelt mit His tag.

Verwendungszweck: Mouse TSPAN8 Protein, His Tag (MALS verified)

Sequenz: Gly 106 - Asn 203

Produktmerkmale: Mouse TSPAN8 Protein, His Tag is expressed from human 293 cells (HEK293). It contains AA Gly 106 - Asn 203 (Accession # Q8R3G9-1).

Endotoxin-Niveau: 1.0 EU per μg

Anwendungsinformationen

Kommentare:

This protein carries a polyhistidine tag at the N-terminus. (10xHis) The protein has a calculated MW of 12.8 kDa. The protein migrates as 15-19 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: PBS, pH 7.4

Lagerung: -20 °C

Informationen zur Lagerung: -20°C

Antigendetails

Target: Tspan-8 (TSPAN8) (Tetraspanin 8 (TSPAN8))

Andere Bezeichnung: TSPAN8

Hintergrund: Tspan8 is 1 of the 33 mammalian members of the tetraspanin family, composed of transmembrane proteins that organize laterally, together or with other membrane partners such as integrins, to form 'tetraspanin webs'. These platforms signal within cells to regulate many cellular processes: adhesion, migration, invasion or survival Tspan8 has been implicated in many types of cancer.Overexpression was reported in glioma and colorectal, esophageal, hepatic, gastric and pancreatic carcinoma. Tspan8 exerts a pro-invasive function by controlling cell-cell and cell-matrix interactions through its association with membrane partners such as α6β4 integrin-protein kinase C (PKC)-activated, E-cadherin, EpCAM, claudin-7 and CD44. Moreover, Tspan8 may be a promising new therapeutic target, as Tspan8-specific antibodies were shown to reduce cell motility, block tumor angiogenesis in vivo.

Molekulargewicht: 12.8 kDa