CD33 Protein (CD33) (APC,His tag)
Kurzübersicht für CD33 Protein (CD33) (APC,His tag) (ABIN7482336)
Target
Alle CD33 Proteine anzeigenProtein-Typ
Spezies
Quelle
Reinheit
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Aufreinigungstag / Konjugat
- Dieses CD33 Protein ist gelabelt mit APC,His tag.
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Verwendungszweck
- APC-Labeled Human Siglec-3 / CD33 Protein, His TagStar Staining
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Sequenz
- Asp 18 - His 259
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Produktmerkmale
- APC-Labeled Human Siglec-3 Protein, His Tag is expressed from human 293 cells (HEK293). It contains AA Asp 18 - His 259 (Accession # AAH28152.1).
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Endotoxin-Niveau
- 1.0 EU per μg
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Kommentare
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This protein carries a polyhistidine tag at the C-terminus. (APC ,10xHis) The protein has a calculated MW of 41.5 kDa.
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Lyophilized
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Buffer
- PBS, 0.2 % BSA, pH 7.4
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Lagerung
- -20 °C
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Informationen zur Lagerung
- -20°C, avoid light
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- CD33
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Andere Bezeichnung
- Siglec-3
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Hintergrund
- Myeloid cell surface antigen CD33 is also known as SIGLEC3, Siglecs (sialic acid binding Ig-like lectins) and GP67, is a single-pass type I membrane protein which belongs to the immunoglobulin superfamily and SIGLEC (sialic acid binding Ig-like lectin) family. Human CD33 / Siglec-3 cD encodes a 364 amino acid (aa) polypeptide with a hydrophobic signal peptide, an N--terminal Ig--like V--type domain, one Ig--like C2--type domains, a transmembrane region and a cytoplasmic tail. CD33 / Siglec-3 usually considered myeloid-specific, but it can also be found on some lymphoid cells. In the immune response, CD33 / Siglec-3 may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. CD33 / Siglec-3 induces apoptosis in acute myeloid leukemia.
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Molekulargewicht
- 41.5 kDa
Target
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