CCL26 Protein
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- Target Alle CCL26 Proteine anzeigen
- CCL26 (Chemokine (C-C Motif) Ligand 26 (CCL26))
- Protein-Typ
- Recombinant
- Spezies
- Human
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Quelle
- Escherichia coli (E. coli)
- Verwendungszweck
- Recombinant Human C-C Motif Chemokine 26 is produced by our E.coli expression system and the target gene encoding Ser27-Leu94 is expressed.
- Produktmerkmale
- Extracellular Domain Protein
- Aufreinigung
- Affinity purification
- Reinheit
- Greater than 95 % as determined by reducing SDS-PAGE.
- Top Product
- Discover our top product CCL26 Protein
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- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Lyophilized
- Buffer
- Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.2.
- Lagerung
- 4 °C,-20 °C
- Informationen zur Lagerung
- Lyophilized protein should be stored at -20°C or lower, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at -20°C or lower for 3 months. The product is shipped at ambient temperature. Upon receipt, store it immediately at the proper temperature.
- Haltbarkeit
- 12 months
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- Target
- CCL26 (Chemokine (C-C Motif) Ligand 26 (CCL26))
- Andere Bezeichnung
- CCL26 (CCL26 Produkte)
- Hintergrund
- Chemokine (C C Motif) Ligand 26 (CCL26) is a novel small cytokine belonging to the CC chemokine family, which involved in immunoregulatory and inflammatory processes. CCL26 is expressed constitutively in thymus, but only transiently in phytohemagglutinin-stimulated peripheral blood mononuclear cells. It specifically binds and induces chemotaxis in T cells and elicits its effects by interacting with the chemokine receptor CCR4. Eotaxin-3/CCL26, along with Eotaxin-1 and Eotaxin-2, selectively activates the CC chemokine receptor 3 (CCR3). The Eotaxin-3-CCR3 interaction may play an important role in allergic diseases such as atopic dermatitis and bronchial asthma. The full-length cDNA for Eotaxin-3 encodes a protein of 94 amino acids with a putative signal peptide of either 23 or 26 amino acid residues. Both the 71 and 68 amino acid residue variants of recombinant Eotaxin-3 demonstrate equal potency in inducing chemotaxis of a human CCR3-transfected cell line. Unlike most other CC chemokines, Eotaxin-3 maps to human chromosome 7q11.2, within 40 kilobases of the Eotaxin-2 loci. Eotaxin-3 and Eotaxin-2 are unique in that they are the only chemokines identified to date that map to chromosome 7.
- Molekulargewicht
- Predicted MW is 8.21 Kda. Protein runs at 13KDa under reducing conditions.
- UniProt
- Q9Y258
- Pathways
- Regulation of Actin Filament Polymerization
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