SNCA Protein (A53T)
Kurzübersicht für SNCA Protein (A53T) (ABIN7316761)
Target
Alle SNCA Proteine anzeigenProtein-Typ
Spezies
Quelle
Reinheit
Güteklasse
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Proteineigenschaft
- A53T
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Verwendungszweck
- Human Alpha-Synuclein (A53T) Protein, Tag Free (MALS verified)
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Sequenz
- Met 1 - Ala 140
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Produktmerkmale
- Human Alpha-Synuclein (A53T), Tag Free is expressed from E.coli cells. It contains AA Met 1 - Ala 140 (Accession # P37840-1 (A53T).
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Endotoxin-Niveau
- 1.0 EU per μg
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Kommentare
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This protein carries no "tag". The protein has a calculated MW of 14.5 kDa. The protein migrates as 15-17 kDa under reducing (R) condition (SDS-PAGE).
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Liquid
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Buffer
- 50 mM HEPES, 100 mM NaCl, pH 7.5
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Lagerung
- -80 °C
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Informationen zur Lagerung
- -70°C
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- SNCA (Synuclein, alpha (SNCA))
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Andere Bezeichnung
- Alpha-Synuclein
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Hintergrund
- Synonyms:N/A,Description:Alpha-synuclein is a neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. It acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DJC5. Abnormalities in alpha-synuclein are implicated in the pathogenesis of Parkinson's disease (PD). Alpha-synuclein is present in Lewy-bodies, the neuropathological hallmark of PD, and the protein and its aggregation have been widely linked to neurotoxic pathways that ultimately lead to neurodegeneration.
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Molekulargewicht
- 14.5 kDa
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Pathways
- Synaptic Membrane, Regulation of G-Protein Coupled Receptor Protein Signaling, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process, Platelet-derived growth Factor Receptor Signaling, Negative Regulation of Transporter Activity, Regulation of long-term Neuronal Synaptic Plasticity
Target
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