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SNCA Protein (A53T)

Dieses Recombinant SNCA-Protein wird in Escherichia coli (E. coli) produziert.
Produktnummer ABIN7316761

Kurzübersicht für SNCA Protein (A53T) (ABIN7316761)

Target

Alle SNCA Proteine anzeigen
SNCA (Synuclein, alpha (SNCA))

Protein-Typ

Recombinant

Spezies

  • 29
  • 7
  • 4
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Human

Quelle

  • 26
  • 13
  • 5
  • 2
  • 2
Escherichia coli (E. coli)

Reinheit

95,00 %

Güteklasse

MALS verified
  • Proteineigenschaft

    A53T

    Verwendungszweck

    Human Alpha-Synuclein (A53T) Protein, Tag Free (MALS verified)

    Sequenz

    Met 1 - Ala 140

    Produktmerkmale

    Human Alpha-Synuclein (A53T), Tag Free is expressed from E.coli cells. It contains AA Met 1 - Ala 140 (Accession # P37840-1 (A53T).

    Endotoxin-Niveau

    1.0 EU per μg
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    Produkt
    Expressionssystem
    Konjugat
    Origin
    Preis ab
    Expressionssystem HEK-293 Cells
    Konjugat His tag
    Origin Human
    Preis ab 13.711,36 €
    Expressionssystem Cell-free protein synthesis (CFPS)
    Konjugat Strep Tag
    Origin Human
    Preis ab 15.754,29 €

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  • Kommentare

    This protein carries no "tag". The protein has a calculated MW of 14.5 kDa. The protein migrates as 15-17 kDa under reducing (R) condition (SDS-PAGE).

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Buffer

    50 mM HEPES, 100 mM NaCl, pH 7.5

    Lagerung

    -80 °C

    Informationen zur Lagerung

    -70°C
  • Target

    SNCA (Synuclein, alpha (SNCA))

    Andere Bezeichnung

    Alpha-Synuclein

    Hintergrund

    Synonyms:N/A,Description:Alpha-synuclein is a neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. It acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DJC5. Abnormalities in alpha-synuclein are implicated in the pathogenesis of Parkinson's disease (PD). Alpha-synuclein is present in Lewy-bodies, the neuropathological hallmark of PD, and the protein and its aggregation have been widely linked to neurotoxic pathways that ultimately lead to neurodegeneration.

    Molekulargewicht

    14.5 kDa

    Pathways

    Synaptic Membrane, Regulation of G-Protein Coupled Receptor Protein Signaling, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process, Platelet-derived growth Factor Receptor Signaling, Negative Regulation of Transporter Activity, Regulation of long-term Neuronal Synaptic Plasticity
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