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Integrin alpha V beta 8 (ITGAV & ITGB8) Heterodimer (AA 31-988) protein (His tag)

Spezies: Maus Wirt: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Produktnummer ABIN7275075
  • Target
    Integrin alpha V beta 8 (ITGAV & ITGB8) Heterodimer
    Protein-Typ
    Recombinant
    Proteineigenschaft
    AA 31-988
    Spezies
    Maus
    Quelle
    • 1
    HEK-293 Cells
    Aufreinigungstag / Konjugat
    His tag
    Verwendungszweck
    Mouse Integrin alpha V beta 8 (ITGAV & ITGB8) Heterodimer Protein
    Sequenz
    Phe31-Val988 (ITGAV) acidic tail & Gly22-Ser679 (ITGB8) basic tail
    Spezifität
    Uni-Prot: P43406 (ITGAV), Q0VBD0 (ITGB8)
    Produktmerkmale
    Recombinant Mouse Integrin alpha V beta 8 (ITGAV & ITGB8) Heterodimer Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Phe31-Val988(ITGAV) acidic tail & Gly22-Ser679(ITGB8) basic tail.
    Reinheit
    > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
    Sterilität
    0.22 μm filtered
    Endotoxin-Niveau
    Less than 1EU per μg by the LAL method.
    Biological Activity Comment
    Immobilized Mouse ITGAV&ITGB8, His Tag at 5μg/ml (100μl/Well) on the plate. Dose response curve for Biotinylated Human Latent TGF beta 1, His Tag with the EC50 of 2.4μg/ml determined by ELISA. See testing image for detail.
  • Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Rekonstitution
    Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/mL is recommended. Dissolve the lyophilized protein in distilled water.
    Buffer
    Lyophilized from 0.22μm filtered solution in PBS ( pH 7.4). Normally 8 % trehalose is added as protectant before lyophilization.
    Lagerung
    -20 °C,-80 °C
    Informationen zur Lagerung
    -20 to -80°C for 12 months as supplied from date of receipt.,-80°C for 3-6 months after reconstitution.,2-8°C for 2-7 days after reconstitution.,Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
    Haltbarkeit
    12 months
  • Target
    Integrin alpha V beta 8 (ITGAV & ITGB8) Heterodimer
    Hintergrund
    Deletions of the genes encoding the integrin αVβ8 (Itgav, Itgb8) have been shown to result in abnormal vascular development in the CNS, including prenatal and perinatal hemorrhage. Other work has indicated that a major function of this integrin in vivo is to promote TGFβ activation.
    Molekulargewicht
    111.6(ITGAV)&76.6(ITGB8) kDa. Due to glycosylation, the protein migrates to 80-140 kDa based on Tris-Bis PAGE result.
    UniProt
    P43406
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