Integrin alpha A1 beta 1 (ITGA1 & ITGB1) Heterodimer (AA 29-1141) protein (His tag)

Produktnummer ABIN7275050

Produktdetails

Target: Integrin alpha A1 beta 1 (ITGA1 & ITGB1) Heterodimer

Protein-Typ: Recombinant

Proteineigenschaft: AA 29-1141

Spezies: Human

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: His tag

Verwendungszweck: Human Integrin alpha 1 beta 1 (ITGA1 & ITGB1) Heterodimer Protein

Sequenz: Phe29-Pro1141 (ITGA1) acidic tail & Gln21-Asp728 (ITGB1) basic tail

Spezifität: Uni-Prot: P56199-1 (ITGA1), P05556-1 (ITGB1)

Produktmerkmale: Recombinant Human Integrin alpha 1 beta 1 (ITGA1 & ITGB1) Heterodimer Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Phe29-Pro1141(ITGA1) acidic tail & Gln21-Asp728(ITGB1) basic tail.

Reinheit: > 95 % as determined by Tris-Bis PAGE

Sterilität: 0.22 μm filtered

Endotoxin-Niveau: Less than 1EU per μg by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/mL is recommended. Dissolve the lyophilized protein in distilled water.

Buffer: Lyophilized from 0.22μm filtered solution in 50 mM Tris, 150 mM NaCl ( pH 7.5). Normally 8 % trehalose is added as protectant before lyophilization.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: -20 to -80°C for 12 months as supplied from date of receipt.,-80°C for 3-6 months after reconstitution.,2-8°C for 2-7 days after reconstitution.,Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Haltbarkeit: 12 months

Antigendetails

Target: Integrin alpha A1 beta 1 (ITGA1 & ITGB1) Heterodimer

Hintergrund: Integrin α1β1 is a heterodimer of the Integrin subunits alpha 1 and beta 1 and is one of four collagen-binding integrins, it preferentially binds Collagens I, IV, VI, XIII and XVI, but also binds Laminin. Integrin α1β1 is widely expressed in mesenchyme and the immune system, as well as a minority of epithelial tissues. It can suppresse EGFR signaling, increase expression of Caveolin-1, reduce production of reactive oxygen species, regulate collagen expression, regulate MMP collagenase and gelatinase activity, and mediates the renal basement membrane disorder Alport syndrome.

Molekulargewicht: 129.1 kDa(ITGA1)&83.2 kDa(ITGB1). Due to glycosylation, the protein migrates to 160-200 kDa based on Tris-Bis PAGE result.