CD96 Protein (CD96) (AA 22-503) (mFc Tag)

Produktnummer ABIN7274270

Recombinant CD96-Protein exprimiert in HEK-293 Cells.

Kurzübersicht für CD96 Protein (CD96) (AA 22-503) (mFc Tag) (ABIN7274270)

Target: CD96

Protein-Typ: Recombinant

Spezies: Human

Quelle: HEK-293 Cells

Reinheit: > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC

Produktdetails

Proteineigenschaft: AA 22-503

Aufreinigungstag / Konjugat: Dieses CD96 Protein ist gelabelt mit mFc Tag.

Verwendungszweck: Human CD96/TACTILE Protein

Sequenz: Val22-Met503

Produktmerkmale: Recombinant Human CD96/TACTILE Protein is expressed from HEK293 with mFc (IgG1) tag at the C-Terminus.It contains Val22-Met503.

Sterilität: 0.22 μm filtered

Endotoxin-Niveau: Less than 1EU per μg by the LAL method.

Biological Activity Comment: Immobilized Human CD96, mFc Tag at 5μg/ml (100μl/Well) on the plate. Dose response curve for Human CD155, hFc Tag with the EC50 of 0.21μg/ml determined by ELISA. See testing image for detail.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/mL is recommended. Dissolve the lyophilized protein in distilled water.

Buffer: Lyophilized from 0.22μm filtered solution in PBS ( pH 7.4). Normally 8 % trehalose is added as protectant before lyophilization.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: -20 to -80°C for 12 months as supplied from date of receipt.,-80°C for 3-6 months after reconstitution.,2-8°C for 2-7 days after reconstitution.,Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Haltbarkeit: 12 months

Antigendetails

Target: CD96

Andere Bezeichnung: CD96

Hintergrund: The receptors CD96 and TIGIT are expressed on the surface of T and natural killer (NK) cells, and recent studies suggest both play important inhibitory roles in immune function. CD96 has been shown to modulate immune cell activity in mice, with Cd96-/- mice displaying hypersensitive NK-cell responses to immune challenge and significant tumor resistance. The counterbalance between the putative inhibitory CD96 and TIGIT receptors and the activating receptor, CD226, offers unique strategies for immuno-oncology drug development.

Molekulargewicht: 79.8 kDa. Due to glycosylation, the protein migrates to 120-160 kDa based on Tris-Bis PAGE result.

UniProt: P40200-2