CAMK1 Protein

Produktnummer ABIN7317143

Dieses Recombinant CAMK1-Protein wird in Escherichia coli (E. coli) produziert.

Kurzübersicht für CAMK1 Protein (ABIN7317143)

Target: CAMK1 (Calcium/calmodulin-Dependent Protein Kinase I (CAMK1))

Protein-Typ: Recombinant

Spezies: Human

Quelle: Escherichia coli (E. coli)

Reinheit: > 85 % as determined by reducing SDS-PAGE.

Produktdetails

Verwendungszweck: Recombinant Human CAMK1/CaMKI-alpha Protein

Sequenz: Leu 2-Leu 370

Produktmerkmale: A DNA sequence encoding the human CAMK1 (NP_003647.1) (Leu 2-Leu 370) was expressed and purified, with two additional amino acids (Gly & Pro) at the N-terminus.

Endotoxin-Niveau: Please contact us for more information.

Anwendungsinformationen

Kommentare:

42 kDa

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile 50 mM Tirs, 150 mM NaCl, 10 % glycerol, pH 7.5

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Antigendetails

Target: CAMK1 (Calcium/calmodulin-Dependent Protein Kinase I (CAMK1))

Andere Bezeichnung: CAMK1

Hintergrund:

Background: Calcium/calmodulin-dependent protein kinase or CaM kinases are serine/threonine-specific protein kinases that are primarily regulated by the Calcium/calmodulin complex. These kinases show a memory effect on activation. CaM kinases activity can outlast the intracellular calcium transient that is needed to activate it. In neurons, this property is important for the induction of synaptic plasticity. Pharmacological inhibition of CaM kinases II blocks the induction of long-term potentiation. Upon activation, CaM kinases II phosphorylates postsynaptic glutamate receptors and changes the electrical properties of the synapse. Calcium/calmodulin-dependent protein kinase type 1D, also known as CaM kinase I delta, CaM kinase ID, CaMKI-like protein kinase, CKLiK and CAMK1D, is a member of the protein kinase superfamily and CaMK subfamily. It contains one protein kinase domain. CAMK1D is broadly expressed. It is highly and mostly expressed in polymorphonuclear leukocytes (neutrophilic and eosinophilic granulocytes) while little or no expression is observed in monocytes and lymphocytes. Engineered overexpression of CAMK1D in non-tumorigenic breast epithelial cells led to increased cell proliferation, and molecular and phenotypic alterations indicative of epithelial-mesenchymal transition (EMT), including loss of cell-cell adhesions and increased cell migration and invasion. CAMK1D is a potential therapeutic target with particular relevance to clinically unfavorable basal-like tumors.

Synonym: Calcium/Calmodulin-Dependent Protein Kinase Type 1; CaM Kinase I; CaM-KI; CaM Kinase I Alpha; CaMKI-Alpha; CAMK1

Molekulargewicht: 41.5 kDa

NCBI Accession: NP_003647

Pathways: Myometrial Relaxation and Contraction, Regulation of Muscle Cell Differentiation, Smooth Muscle Cell Migration