MUC16 Protein (Biotin)

Produktnummer ABIN7319819

Dieses Recombinant MUC16-Protein wird in Human Cells produziert.

Kurzübersicht für MUC16 Protein (Biotin) (ABIN7319819)

Target: MUC16 (CA125) (Mucin 16, Cell Surface Associated (CA125))

Protein-Typ: Recombinant

Spezies: Human

Quelle: Human Cells

Reinheit: >95 % as determined by reducing SDS-PAGE.

Produktdetails

Aufreinigungstag / Konjugat: Dieses MUC16 Protein ist gelabelt mit Biotin.

Verwendungszweck: Recombinant Human CA125/MUC16 (C-Fc-Avi) Biotinylated

Sequenz: Gly12660-Met12923

Produktmerkmale: Biotinylated Recombinant Human Mucin-16 is produced by our Mammalian expression system and the target gene encoding Gly12660-Met12923 is expressed with a Fc, Avi tag at the C-terminus.

Endotoxin-Niveau: < 1.0 EU per μg as determined by the LAL method.

Anwendungsinformationen

Kommentare:

80-120 kDa

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from a 0.2 μm filtered solution of 50 mM Tris-HCl, 100 mM Glycine, pH 7.5.

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Antigendetails

Target: MUC16 (CA125) (Mucin 16, Cell Surface Associated (CA125))

Andere Bezeichnung: CA125

Hintergrund:

Background: MUC16, also known as the CA125 antigen, is a mucin protein that may be found in type I transmembrane or secreted forms that are used monitor the progress of epithelial ovarian cancer therapy. MUC16 is over-expressed by tumor cells including ovarian and mesothelial cancers. The transmembrane form can adhere to mesothelin in the peritoneum, facilitating metastasis of ovarian cancer to the peritoneal cavity. MUC16 also binds galectin-1 on immune cells and enhances its expression on tumor cells. MUC16-expressing tumors adhere to NK cells, down-regulate CD16 and suppress NK response, which may promote immune evasion. MUC16 is also cyclically expressed in the endometrium and may contribute to immune privilege during pregnancy. In the eye, MUC16 and other mucins protect the cornea and keep it hydrated. It is altered on the conjunctival epithelium of patients with non-Sjogren dry eye syndrome.

Synonym: CA125 ovarian cancer antigen, CA125, CA-125, CA125MUC-16, FLJ14303, MUC16,mucin 16, cell surface associated, mucin-16

Molekulargewicht: 57.3 kDa

UniProt: Q8WXI7